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Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction.
Subst Abuse Rehabil
December 2024
The Joint Innovation Center for Health & Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, People's Republic of China.
Background: Opioid-based medications are powerful analgesics commonly prescribed for pain management, but they are also highly addictive. The over-prescription of opioids analgesics has triggered current opioid crisis, which now has expanded to heroin and illicit synthetic opioids like fentanyl and its analogues. The side effects of fentanyl abuse have been well recognized, yet the underlying molecular adaptations across brain regions upon fentanyl exposure remain elusive.
View Article and Find Full Text PDFA Genetic Polymorphism Underlying Alternative Reproductive Tactics in Eurycea Salamanders.
Mol Ecol
December 2024
Department of Ecology, Evolution, and Organismal Biology, Kennesaw State University, Kennesaw, Georgia, USA.
Alternative reproductive tactics are discrete, intrasexual differences in reproductive behaviour within a population. In some cases, these complex phenotypes are determined by autosomal supergenes or sex chromosomes-both of which exhibit reduced recombination and thus enable the linked inheritance of co-adapted alleles from multiple loci. Most alternative reproductive tactics in amphibians are plastic (and reversible), environmentally determined and lacking morphological differentiation, but a striking exception is found in the two-lined salamander (Eurycea bislineata) species complex.
View Article and Find Full Text PDFComprehensive characterization of European house dust contaminants: Concentrations and profiles, geographical variability, and implications for chemical regulation and health risk.
Sci Total Environ
December 2024
Flemish Institute for Technological Research (VITO), Unit Materials and Chemistry (MATCH), 2400 Mol, Belgium.
Article Synopsis
- - This study explores the levels and geographical differences of contaminants found in house dust across Europe, identifying over 1200 anthropogenic compounds using advanced techniques like mass spectrometry and suspect screening.
- - The research indicates that contaminant concentrations vary less than threefold within Europe, showing similarities with North American dust due to shared consumer products and materials.
- - It highlights geographical patterns, revealing that certain contaminants increased from north to south (like PAHs and chlorinated paraffins), whereas others, like biocides, decreased; it also emphasizes a significant risk from older, restricted contaminants, like DEHP and PCBs, despite limited toxicity data available for newer compounds.
Microbial Biodiversity in Sediment from the Amuyo Ponds: Three Andean Hydrothermal Lagoons in Northern Chile.
Microorganisms
November 2024
Laboratory of Biochemistry, Biomedical Department, Health Sciences Faculty, Centre for Biotechnology and Bioengineering (CeBiB), Universidad de Antofagasta, Antofagasta 1240000, Chile.
The Amuyo Ponds (APs) are a group of three brackish hydrothermal lagoons located at 3700 m above sea level in a pre-Andean setting in the Atacama Desert. Each pond shows a conspicuous green (GP), red (RP), or yellow (YP) coloration, and discharges water rich in arsenic and boron into the Caritaya River (Camarones Basin, northern Chile). Microorganisms are subjected to harsh environmental conditions in these ponds, and the microbial composition and diversity in the Amuyo Ponds' sediments are unknown.
View Article and Find Full Text PDFAn exceptionally preserved fossil assemblage from the early Jurassic of Chongqing (China) reveals a complex lacustrine ecosystem.
Sci Rep
November 2024
Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, 100044, China.
One of the five greatest mass extinction events in the history of life occurred at the end of the Triassic (~ 201 million years ago), as confirmed by profound loss of life in marine realm. Terrestrial ecosystems were also suffered but the extent of life loss and timing of subsequent recovery remain equivocal, largely because of scarcity of fossil record. Here we report an exceptionally-preserved fossil assemblage, Yuzhou Biota, from the Sinemurian (~ 199-193 Ma), Early Jurassic lacustrine deposits of northern Chongqing, China.
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