Urine cytology is a sensitive and specific method in detecting urothelial carcinoma of the urinary bladder, particularly the high-grade ones. However, the cytologic features of nonneoplastic lesions of the lower urinary tract, including nephrogenic adenoma, are nonspecific and may cause false positive diagnosis. Recent evidence has demonstrated that nephrogenic adenoma is a true "nephrogenic" lesion derived from the exfoliated and implanted renal tubular cells in the urinary tract. This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract. We report here that PAX2 immunostaining can also be used in urine cytology specimen to identify nephrogenic adenoma. Combination of PAX2 immunostaining and cytologic analysis may increase the accuracy in identifying this benign lesion in urine cytology specimen and therefore reduce unnecessary repeat cystoscopy and biopsy procedures. This may be a cost effective follow- up method for patients with an established diagnosis of nephrogenic adenoma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/dc.20751 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Nephrogenic adenoma of the urinary bladder is a rare, benign lesion associated with prior inflammation or irritation of the urothelium. Although typically benign, nephrogenic adenoma can present diagnostic challenges due to its potential to mimic malignant tumors of the urinary tract. In this report, we present a case of an elderly woman with a history of recurrent urinary tract infections and bladder stone surgery who developed nephrogenic adenoma.
View Article and Find Full Text PDFMalignant transformation of nephrogenic adenoma of the bladder: case report and literature review.
Transl Androl Urol
November 2024
Department of Urology, The Second Hospital of Dalian Medical University, Dalian, China.
Background: Nephrogenic adenoma (NA) is a rare benign tumor that can develop at any site of the urinary system, with the bladder being the most common, followed by the urethra, ureters, renal pelvises, etc. Currently, it is unclear what the pathogenesis of NA is. This study discussed a rare case of malignant transformation from NA to mesonephric adenocarcinoma of the bladder.
View Article and Find Full Text PDFNephrogenic Adenoma: A Pitfall on Frozen Section of Urethral Strictures.
Int J Surg Pathol
October 2024
Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada.
Urethral strictures are a common cause of urinary obstruction which can be treated with surgical resection. Frozen sections are rare and pose a diagnostic challenge to pathologists due to the presence of benign lesions such as nephrogenic adenoma. We retrospectively examined all specimens of urethral stricture resections submitted to pathology at our institution from 2012 to 2022 (n = 258).
View Article and Find Full Text PDFAn unusual intravesical tumor: nephrogenic adenoma.
An Pediatr (Engl Ed)
August 2024
Cirugía Pediátrica, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain; Consorci Sanitari Alt Penedès i Garraf, Sant Pere de Ribes, Barcelona, Spain.
Nephrogenic adenomas are benign lesions that develop within the urinary tract. Most often developing within the urinary bladder, these lesions have a debatable etiopathogenesis, with hamartoma, rest hyperplasia, and transplantation of renal tubular cells being the most widely accepted ones. Nephrogenic adenomas develop more often in adult males, and predisposing factors for their development are prior urinary system injury, infection, or malignancy, with a subset of cases developing in renal transplant patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!