Accurate correction and restoration of facial contour defects have historically posed arduous challenges for reconstructive and aesthetic surgeons, but technological innovations in the design and manufacture of facial prostheses have significantly improved the precision, fit, and reliability of these restorative devices. This article discusses the experience with and benefits obtained by the use custom implants created using CT imaging and computer-aided design and manufacture.
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http://dx.doi.org/10.1016/j.fsc.2007.09.001 | DOI Listing |
Expert Opin Drug Deliv
January 2025
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Moscow, Russia.
Introduction: The pursuit of linear dosage in pharmacy is essential for achieving consistent therapeutic release and enhancing patient compliance. This review provides a comprehensive summary of zero-order drug delivery systems, with a particular focus on reservoir-based systems emanated from different microfabrication technologies.
Areas Covered: The consideration of recent advances in drug delivery systems is given to encompass the key areas including the importance of achieving a constant drug release rate for therapeutic applications.
J Biomed Mater Res A
January 2025
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
Bone tissue regeneration can be affected by various architectonical features of 3D porous scaffold, for example, pore size and shape, strut size, curvature, or porosity. However, the design of additively manufactured structures studied so far was based on uniform geometrical figures and unit cell structures, which often do not resemble the natural architecture of cancellous bone. Therefore, the aim of this study was to investigate the effect of architectonical features of additively manufactured (aka 3D printed) titanium scaffolds designed based on microtomographic scans of fragments of human femurs of individuals of different ages on in vitro response of human bone-derived mesenchymal stem cells (hMSC).
View Article and Find Full Text PDFBiotechnol Notes
November 2024
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell growth. The beginnings of this systematized technology, which took place in the last century, were used to explore the secrets of life. Currently, with its easy integration with other technologies or disciplines, cell-free synthetic biology is developing into a powerful and effective means of understanding, exploiting, and extending the structure and function of natural living systems.
View Article and Find Full Text PDFApplications of genetic code expansion in live cells are widespread and continually emerging, yet they have been limited by their reliance on the supplementation of non-standard amino acids (nsAAs) to cell culturing media. While advances in cell-free biocatalysis are improving nsAA synthesis cost and sustainability, such processes remain reliant on multi-step processes of product isolation followed by supplementation to engineered cells. Here, we report the design of a modular and genetically encoded system that combines the steps of biosynthesis of diverse phenylalanine derivatives, which are the most frequently used family of nsAAs for genetic code expansion, and their site-specific incorporation within target proteins using a single engineered bacterial host.
View Article and Find Full Text PDFSmall
January 2025
Faculty of Materials Science and Engineering, Analysis and Testing Research Center, Kunming University of Science and Technology, Kunming, 650093, P. R. China.
Modulating electronic structure to balance the requirement of both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is crucial for developing bifunctional catalysts. Herein, phase transformation engineering is utilized to separately regulate catalyst structure, and the designed NiFe@Ni/Fe-MnOOH schottky heterojunction exhibits remarkable bifunctional electrocatalytic activity with low overpotentials of 19 and 230 mV at 10 mA cm for HER and OER in 1M KOH, respectively. Meanwhile, an anion-exchange membrane water electrolyzer employing NiFe@Ni/Fe-MnOOH as electrodes shows low voltages of 1.
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