The paper deals with the information provision and use of mathematical statistical and mathematical economic methods in the substantiation of measures provided by the socioeconomic development programs. The development of a package of human health maintenance measures may involve 2 stages: (1) analysis of long-term data on the man-caused pollution of environmental objects, socioeconomic conditions, and the medicodemographic situation; (2) medium-range forecast of indicators. Testing the proposed approaches applied in Irkutsk has ascertained that the investment area development causes a steady-state decrease in morbidity rates in all population groups and a reduction in disorders-caused economic damages.

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