SERS aptasensors for protein recognition based on Au nanoparticles labeled with aptamers and Raman reporters have been developed, which opens a new way for protein recognition of high sensitivity and selectivity.
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Mitochondrial Protein MjEF-Tu is Secreted into Host Plants by Nematodes Eliciting Immune Signaling and Resistance.
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College of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Little is known about plant-parasitic animal-derived pathogen-associated molecular pattern (PAMP)/ pattern-recognition receptor (PRR) pairs. Additionally, mitochondrial proteins have not previously been reported to be secreted into hosts by pathogens. Here, it is found that the Meloidogyne javanica elongation factor thermo unstable (EF-Tu) (MjEF-Tu) located in the nematode mitochondria is up-regulated and secreted into the host plant during nematode parasitism.
View Article and Find Full Text PDFVersatile roles of disordered transcription factor effector domains in transcriptional regulation.
FEBS J
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Molecular Biology and Genetics Department, Ihsan Dogramaci Bilkent University, Ankara, Turkey.
Transcription, a crucial step in the regulation of gene expression, is tightly controlled and involves several essential processes, such as chromatin organization, recognition of the specific genomic sequences, DNA binding, and ultimately recruiting the transcriptional machinery to facilitate transcript synthesis. At the center of this regulation are transcription factors (TFs), which comprise at least one DNA-binding domain (DBD) and an effector domain (ED). Although the structure and function of DBDs have been well studied, our knowledge of the structure and function of effector domains is limited.
View Article and Find Full Text PDFDivergent Chemoenzymatic Synthesis of Sulfated Ganglio-Oligosaccharides for Probing Ligand Requirements of Glycan Binding Proteins.
Angew Chem Int Ed Engl
January 2025
University of Georgia, Complex Carbohydrate Research Center and Department of Chemistry, 315 Riverbend Road, 30602, Athens, UNITED STATES OF AMERICA.
Sulfoglycolipids are an important class of acidic glycosphingolipids implicated in a multitude of biological processes. Little is known about the interactome of sulfated gangliosides, and it is not well understood how a possible interplay between sialylation and sulfation influences molecular recognition. We describe a chemoenzymatic strategy that readily provided a panel of twenty-one sulfated and sialylated ganglio-oligosaccharides.
View Article and Find Full Text PDFRecent insights and perspectives into the role of the miRNA‑29 family in innate immunity (Review).
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Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu 214041, P.R. China.
Innate immunity is the first line of defence against pathogenic microorganisms and is nearly universal among eukaryotes. The innate immune system is composed of various organs, cells and immune molecules. MicroRNAs (miRs) are a class of small non‑coding RNAs (~22 nucleotides) that are widely involved in post‑transcriptional regulation of proteins within the innate immune system through the recognition of seed sequences.
View Article and Find Full Text PDFMolecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in -Acyltransferase Polyketide Synthases.
JACS Au
January 2025
Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
Polyketide synthases (PKSs) are multidomain enzymatic assembly lines that biosynthesize a wide selection of bioactive natural products from simple building blocks. In contrast to their -acyltransferase (AT) counterparts, -AT PKSs rely on stand-alone ATs to load extender units onto acyl carrier protein (ACP) domains embedded in the core PKS machinery. -AT PKS gene clusters also encode stand-alone acyl hydrolases (AHs), which are predicted to share the overall fold of ATs but function like type II thioesterases (TEs), hydrolyzing aberrant acyl chains from ACP domains to promote biosynthetic efficiency.
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