[A case of hypophyseal and pineal germinoma].

Endokrynol Pol

Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami Akademii Medycznej, Wrocław.

Published: April 2008

A case of 19-year-old male with idiopathic diabetes insipidus diagnosed 9 years ago. 1.5 years from the onset of the disease vision disturbances, neurologic deficiencies and symptoms of hypopituitarism showed up. MRI examination revealed an advanced hypophyseal and pineal gland tumor--germinoma. Total regression was achieved with radio- and chemotherapy. For 7 years from the end of treatment patient has not declared any complains except for vision disturbances and hypopituitarism has been substituted successfully. The case puts on the necessity of a strict endocrinologic and radiologic follow-up in patients with idiopathic diabetes insipidus due to the possibility of existing potentially curable disease ie. intracranial tumor.

Download full-text PDF

Source

Publication Analysis

Top Keywords

hypophyseal pineal
8
idiopathic diabetes
8
diabetes insipidus
8
vision disturbances
8
case hypophyseal
4
pineal germinoma]
4
germinoma] case
4
case 19-year-old
4
19-year-old male
4
male idiopathic
4

Similar Publications

Previous studies have confirmed that methylation regulates gene transcription in the hypothalamus-pituitary-gonadal axis during puberty initiation, but little is known about the regulation of DNA methylation on gene expression in the pineal gland. To screen pineal gland candidate genes related to the onset of goat puberty and regulated by genome methylation, we collected pineal glands from prepubertal and pubertal female goats, then, determined the DNA methylation profile by whole genome bisulfite sequencing and the transcriptome by RNA sequencing on Illumina HiSeqTM2500. We analyzed differentially expressed genes between the Pre group and Pub group using the DESeq2 software (version 1.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on the expression of miRNA-375 in the hypothalamic-pituitary-gonadal axis of female Hu sheep, involving cloning its precursor sequence and comparing it to data in various species.
  • It used real-time PCR to measure the levels of miR-375 in various tissues, finding that its expression was highest in the pineal gland compared to other reproductive and brain tissues.
  • The research identified that miR-375 is connected to multiple biological processes and pathways, particularly the Hippo and Wnt pathways, suggesting it plays a key role in regulating sheep reproduction.
View Article and Find Full Text PDF

Objective: Patients with obsessive-compulsive disorder (OCD) can have hyperactivity of the hypothalamic-pituitary-adrenal axis and may have increased secretion of adrenocorticotropic hormone and cortisol and reduced secretion of melatonin. Examination of pineal gland volumes in patients with OCD compared to healthy controls, thus, is an important consideration and the focus of this study.

Methods: A total of 20 patients with OCD and 20 healthy controls were enrolled.

View Article and Find Full Text PDF
Article Synopsis
  • Intracranial seminoma is a rare type of cancer that starts in special cells in the brain, often found in the pineal or pituitary gland.
  • A 20-year-old patient had headaches and vision problems and was diagnosed with this cancer after an MRI showed issues with his pituitary stalk.
  • He had surgery to remove the tumor and received treatment, but it came back a year later, leading to another surgery and ongoing treatments, although he still faces some health challenges.
View Article and Find Full Text PDF

Overlapping action of melatonin and female reproductive hormones-Understand the impact in pregnancy and menopause.

Adv Protein Chem Struct Biol

July 2024

CICS-UBI-Health Sciences Research Centre, Universidade da Beira Interior, Covilhã, Portugal; Instituto Politécnico da Guarda, Guarda, Portugal. Electronic address:

Melatonin is an indolamine secreted to circulation by the pineal gland according to a circadian rhythm. Melatonin levels are higher during nighttime, and the principal function of this hormone is to organize the temporal night and day distribution of physiological adaptive processes. Besides hormonal pineal production, melatonin is synthesized in various organs and tissues like the ovaries or the placenta for local utilization.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!