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Safety and Effectiveness of a Biosimilar Recombinant Growth Hormone in Adults with Growth Hormone Deficiency: Analysis of Final Data from PATRO Adults, an International Post-Marketing Surveillance Study.
Drug Des Devel Ther
December 2024
HEXAL AG (a Sandoz company), Holzkirchen, Germany.
Purpose: Long-term studies are needed to investigate the safety of recombinant human growth hormone (rhGH) for the treatment of growth hormone deficiency (GHD) in routine practice. The objective of this study was to evaluate the safety and effectiveness of biosimilar rhGH (somatropin; Omnitrope) in adults with GHD.
Methods: PAtients TReated with Omnitrope (PATRO) Adults was a post-marketing surveillance study conducted across Europe.
Long-term safety and effectiveness of a somatropin biosimilar (Omnitrope) in children requiring growth hormone therapy: analysis of final data of Italian patients enrolled in the PATRO children study.
Endocrine
November 2024
Pediatric Unit, IRCCS AOU of Bologna, Bologna, Italy.
Purpose: Omnitrope (a somatropin biosimilar), used to treat growth disturbances, is considered to have a good safety profile in children. Here, we present the analysis of final data of the Italian cohort of the PAtients TReated with Omnitrope (PATRO) Children study.
Methods: This multicenter, open-label, longitudinal, post-marketing surveillance study enrolled eligible children during 2010-2018.
Growth hormone treatment in children with Prader-Willi syndrome: safety and effectiveness data from the PATRO Children study.
Ther Adv Endocrinol Metab
September 2024
HEXAL AG (a Sandoz Company), Holzkirchen, Germany.
Article Synopsis
- The study looked at how safe and effective a medicine called Omnitrope (a type of human growth hormone) is for kids with a condition called Prader-Willi syndrome (PWS).
- 235 kids were part of the study, and researchers watched for any side effects while they were treated.
- After 3 years of treatment, most kids saw improvements in their height, which means the medicine really helped them grow!
Follicle-Stimulating Hormone Sweetness: How Carbohydrate Structures Impact on the Biological Function of the Hormone.
Arch Med Res
December 2024
Department of Biomedical Sciences, State University of New York at Albany, Albany, NY, USA.
Follicle-stimulating hormone (FSH), or follitropin, exists in multiple molecular forms due largely to its protein-carbohydrate composition and the complexity of the glycans attached to the protein core. The heterogeneity of gonadotropins exists in two forms, macroheterogeneity, which results from the absence of one or two oligosaccharide chains in the ß-subunit, and microheterogeneity which results from variation in the structures and complexity of the glycans attached to the hormone. In the clinical arena, FSH compounds are widely used by fertility specialists to promote ovarian follicle growth and maturation to a preovulatory follicle containing a fertilization-competent oocyte.
View Article and Find Full Text PDFEvolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review.
Hum Reprod Update
October 2024
IVIRMA Global Research Alliance, IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.
Background: The establishment and maintenance of pregnancy depend on endometrial competence. Asherman syndrome (AS) and intrauterine adhesions (IUA), or endometrial atrophy (EA) and thin endometrium (TE), can either originate autonomously or arise as a result from conditions (i.e.
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