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http://dx.doi.org/10.1104/pp.107.106641 | DOI Listing |
Nat Commun
November 2024
Hubei Key Laboratory of Marine Geological Resources, China University of Geosciences, Wuhan, China.
Oceanic gateways play a crucial role in controlling global ocean circulation. However, gateway effects on low-latitude deep-water circulation are poorly understood. The South China Sea, located in the western Pacific, was influenced by changes in the equatorial and low-latitude gateways, which recorded significant oceanographic variations since the Oligocene.
View Article and Find Full Text PDFJ Cheminform
November 2024
AI Chemistry, Ro5, 2801 Gateway Drive, Irving, 75063, TX, USA.
Background: Target identification and hit identification can be transformed through the application of biomedical knowledge analysis, AI-driven virtual screening and robotic cloud lab systems. However there are few prospective studies that evaluate the efficacy of such integrated approaches.
Results: We synergistically integrate our in-house-developed target evaluation (SpectraView) and deep-learning-driven virtual screening (HydraScreen) tools with an automated robotic cloud lab designed explicitly for ultra-high-throughput screening, enabling us to validate these platforms experimentally.
Parasit Vectors
November 2024
Molecular Biology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt.
J Nat Prod
November 2024
NAICONS SRL, 20139 Milan, Italy.
Natural products are a sustainable resource for drug discovery, but their identification in complex mixtures remains a daunting task. We present an automated pipeline that compares, harmonizes and ranks the annotations of LC-HRMS data by different tools. When applied to 7,400 extracts derived from 6,566 strains belonging to 86 actinomycete genera, it yielded 150,000 molecules after processing over 50 million MS features.
View Article and Find Full Text PDFCereb Cortex
January 2025
Department of Neuroscience, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, United States.
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