AI Article Synopsis
- The study aimed to determine if asymptomatic spontaneous cerebral emboli (SCE) can predict depression in older adults.
- The research involved 96 non-depressed older participants over 2.5 years, measuring SCE presence and analyzing its effect on depression levels at follow-up.
- While the prevalence of depression differed between SCE-positive and negative subjects, the severity of depressive symptoms was affected only when accounting for cardiovascular risk factors, suggesting a possible link between SCE and late-life depression.
Article Abstract
Objective: To examine whether asymptomatic spontaneous cerebral emboli (SCE) predicts subsequent depression in older people.
Methods: Prospective cohort study with 2.5 years of follow-up including 96 nondepressed older subjects in primary care. Presence of SCE was measured at baseline by transcranial Doppler of the middle cerebral artery and modeled on depression at follow-up using multiple logistic and linear regression analyses.
Results: The prevalence of depressive disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria did not differ significantly between SCE-positive and SCE-negative subjects (27% versus 12%), while the severity of depressive symptoms did (Geriatric Depression Scale: beta = 0.22; Montgomery-Asberg Depression Rating Scale: beta = 0.25). These differences disappeared after adjustment for cardiovascular risk factors.
Conclusion: These preliminary findings suggest that asymptomatic SCE may be an interceding factor in the development of late-life depression, consistent with the vascular depression hypothesis.
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| http://dx.doi.org/10.1097/JGP.0b013e318151f99d | DOI Listing |
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