Fetal growth plate: a developmental model of cellular adaptation to hypoxia.

Ann N Y Acad Sci

Department of Anatomy, UCSF, San Francisco, California, USA.

Published: November 2007

Fetal growth plate chondrocyte is a unique mesenchymal tissue, as it is avascular and hypoxic. Yet, chondrocytes not only survive in this environment, but also undergo all cellular processes (proliferation, growth arrest, differentiation, etc.) required for normal endochondral bone development. A crucial mediator of the adaptive response of cells to hypoxia is a transcription factor named hypoxia-inducible factor 1alpha (Hif-1alpha). One target of Hif-1alpha transcriptional activation is the angiogenic factor vascular endothelial growth factor (VEGF), whereas Hif-1alpha accumulation is controlled by the von Hippel-Lindau (VHL) tumor suppressor, an E3-ubiquitin ligase that induces its degradation by the proteasome. We, and others, demonstrated that each component of this pathway is a critical regulator of endochondral bone development. In particular, we previously established that Hif-1alpha is a survival factor for hypoxic chondrocytes, and that it also negatively regulates cell proliferation. Interestingly, we also showed that hypoxia increases extracellular matrix accumulation in a Hif-1alpha-dependent fashion. This suggested that Hif-1alpha could be critically important not only for cell survival and proliferation but also for cell differentiation. We recently demonstrated that Hif-1alpha is indeed a differentiation factor since it is required in mesenchymal cells both for early chondrogenesis, and for joint development.

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1402.076DOI Listing

Publication Analysis

Top Keywords

fetal growth
8
growth plate
8
hypoxic chondrocytes
8
endochondral bone
8
bone development
8
factor
6
hif-1alpha
6
plate developmental
4
developmental model
4
model cellular
4

Similar Publications

Using Transcriptomic Signatures to Elucidate Individual and Mixture Effects of Inorganic Arsenic and Manganese in Human Placental Trophoblast HTR-8/SVneo Cells.

Toxicol Sci

January 2025

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.

Prenatal exposure to the toxic metal inorganic arsenic (iAs) is associated with adverse pregnancy and fetal growth outcomes. These adverse outcomes are tied to physiological disruptions in the placenta. While iAs co-occurs in the environment with other metals such as manganese (Mn), there is a gap in the knowledge of the effects of metal-mixtures on the placenta.

View Article and Find Full Text PDF

Intrahepatic portosystemic shunt: salvage mechanism for oligohydramnios complicating fetal growth restriction.

Ultrasound Obstet Gynecol

January 2025

Ultrasound Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

Objective: Portosystemic shunts in growth-restricted fetuses are more common than previously thought. We aimed to describe fetuses with growth restriction and transient oligohydramnios in which a congenital intrahepatic portosystemic shunt (CIPSS) was noted during follow-up.

Methods: This was a retrospective study of all fetuses diagnosed with growth restriction and transient oligohydramnios during a 5-year period in a large tertiary referral center.

View Article and Find Full Text PDF

The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. H-MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as well as those with neurological diseases. This review aims to provide readers with an understanding of 1) the basic principles and technical considerations relevant to H-MRS in the fetal-neonatal brain and 2) the role of H-MRS in early fetal-neonatal development brain research.

View Article and Find Full Text PDF

Improving Image Quality and Decreasing SAR With High Dielectric Constant Pads in 3 T Fetal MRI.

J Magn Reson Imaging

January 2025

Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Background: At high magnetic fields, degraded image quality due to dielectric artifacts and elevated specific absorption rate (SAR) are two technical challenges in fetal MRI.

Purpose: To assess the potential of high dielectric constant (HDC) pad in increasing image quality and decreasing SAR for 3 T fetal MRI.

Study Type: Prospective.

View Article and Find Full Text PDF

Dias-Logan syndrome with a p.Leu360Profs*212 heterozygous pathogenic variant of in a Chinese patient: A case report.

SAGE Open Med Case Rep

January 2025

Department of Reproductive Medicine, Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine & Hangzhou Red Cross Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Dias-Logan syndrome, also known as intellectual developmental disorder with persistence of fetal hemoglobin (HbF), or -related intellectual developmental disorder, is an extremely rare neurogenetic disorder characterized by intellectual disability (ID), delayed psychomotor development, variable dysmorphic features, and asymptomatic persistence of fetal hemoglobin. The prevalence and incidence of this condition are currently unknown. We report an 8-year-old Han Chinese male patient with Dias-Logan syndrome who carries a heterozygous pathogenic variant, c.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!