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Coccidioidal Endophthalmitis Secondary to Coccidoides Posadasii: A Rare Infection in Humans.
Retin Cases Brief Rep
October 2024
Cleveland Clinic Cole Eye Institute, Cleveland, OH 44106.
Purpose: To describe the first case of Coccidioides posadasii endophthalmitis.
Methods: A 41-year-old man referred for acute retinal necrosis (ARN) failing 3 months of outpatient treatment was referred for further management. Three consecutive pars plana vitrectomies were required to identify C.
Pathobiology of Fungal Endophthalmitis: A Major Review.
ACS Infect Dis
September 2024
Jhaveri Microbiology Centre, Brien Holden Eye Research Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana 500034, India.
Fungal endophthalmitis is a chronic inflammatory condition of the eye's posterior segment that can lead to irreversible vision loss. While relatively rare in western countries, its incidence is notably higher in Asia, particularly India. The condition's prevalence is exacerbated by factors such as intravenous drug use, antibiotics, and ocular surgeries.
View Article and Find Full Text PDFTransfer learning predicts species-specific drug interactions in emerging pathogens.
bioRxiv
June 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Machine learning (ML) algorithms are necessary to efficiently identify potent drug combinations within a large candidate space to combat drug resistance. However, existing ML approaches cannot be applied to emerging and under-studied pathogens with limited training data. To address this, we developed a transfer learning and crowdsourcing framework (TACTIC) to train ML models on data from multiple bacteria.
View Article and Find Full Text PDFPredatory bacteria prevent the proliferation of intraocular and fluoroquinolone-resistant .
Microbiology (Reading)
February 2024
Charles T. Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Endogenous endophthalmitis caused by Gram-negative bacteria is an intra-ocular infection that can rapidly progress to irreversible loss of vision. While most endophthalmitis isolates are susceptible to antibiotic therapy, the emergence of resistant bacteria necessitates alternative approaches to combat intraocular bacterial proliferation. In this study the ability of predatory bacteria to limit intraocular growth of , , and was evaluated in a New Zealand white rabbit endophthalmitis prevention model.
View Article and Find Full Text PDFInvolvement of Tn3 transposon in formation and transmission of hypervirulent and carbapenem-resistant .
Microbiol Spectr
December 2023
Department of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Carbapenem-resistant (CRKP) is resistant to most common antibiotics, becoming the most important and prevalent nosocomial opportunity pathogen. Besides, can also cause severe community-acquired infections, such as primary liver abscess and endophthalmitis. These pathogens are commonly referred to as hvKp.
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