India is getting to be known as a hot destination for executing clinical trials. It is witnessing the frenzied entry of pharma sponsor companies and contract research organizations and the movement of Indian non-healthcare groups into clinical research. In this mad melee, what are the determinants of success? How real is the promise of clinical research in India and what will make or break a new entrant in this business? This article attempts to describe these challenges and focuses on the resilient success criteria that the contract clinical research industry in India has tested every newcomer against.
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http://dx.doi.org/10.1016/j.cct.2007.10.006 | DOI Listing |
Integr Environ Assess Manag
January 2025
Mu Gamma Consultants Pvt. Ltd, Gurgaon, India, 122018.
Microplastics (MPs) have become a notable concern and are released into the environment through the disposal or fragmentation of large plastics. Rivers have been the major pathways for MPs present in the oceans, which significantly affects the marine environment. In the current study, water samples were collected from the upper stream and downstream of Damanganga and Tapi rivers across different sites in the state of Gujarat, India for exploration of MPs contamination.
View Article and Find Full Text PDFJ Mol Model
January 2025
PG & Research Department of Mathematics, Sanatana Dharma College, Kerala University, Alappuzha, Kerala, 688003, India.
Holey nanographene, an allotrope of carbon arranged in two dimensions, has gained remarkable attention as a nanomaterial with several potential uses in numerous industries, such as electronics, energy storage, healthcare, and environmental cleanup, because of its high carrier mobility, flexibility, transparency, high surface area, conductivity, and chemical stability. The fundamental holey nanographene is assembled in a linear form to create the holey nanographene chain (HNC) that is being discussed. To fully utilize it in various applications, it is essential to comprehend the basic ideas guiding its behavior at the nanoscale; for that, we find various topological indices for this holey nanographene chain using the cut method.
View Article and Find Full Text PDFPharmaceutics
January 2025
Research Centre for Life Science and Healthcare, Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute (CBI), University of Nottingham Ningbo China, Ningbo 315000, China.
Malignant growth is expected to surpass other significant causes of death as one of the top reasons for dismalness and mortality worldwide. According to a World Health Organization (WHO) study, this illness causes approximately between 9 and 10 million instances of deaths annually. Chemotherapy, radiation, and surgery are the three main methods of treating cancer.
View Article and Find Full Text PDFMolecules
January 2025
Independent Researcher, 1802 Stanford Avenue, Duluth, MN 55811, USA.
The development of chirality descriptors for quantitative chirality structure-activity relationship (QCSAR) modeling has always attracted attention, owing to the importance of chiral molecules in pharmaceutical, agriculture, food, and fragrance industries, and environmental toxicology. The utility of a multidimensional space of novel relative chirality indices (RCIs) in the QCSAR modeling of twenty CCR2 antagonists is reported upon in this paper. The numerical characterization of chirality by the RCI approach gives a large pool of chirality descriptors with different degrees of mutual correlation (the correlation coefficient among the computed descriptors varied from 0.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Department of Mechanical and Industrial Engineering, Tallinn University of Technology, Ehitajate Tee 5, 19086 Tallinn, Estonia.
Interpenetrating phase composites are a novel class of heterogeneous structures that have recently gained attention. In these types of composites, one of the phases is topologically continuous and can maintain its structural integrity even if the other phase is removed. These composites are generally fabricated by casting, where the reinforcement penetrates into the precursor matrix as a continuous phase.
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