AI Article Synopsis

  • * Eight of these compounds, derived from four distinct plant species, demonstrated significant anti-parasitic activity.
  • * The active compounds included various chemical classes, such as a new and a known pterocarpan, a chalcone, four withasteroids, and a benzoquinone.

Article Abstract

Two hundred fifteen compounds isolated from plants of Northeastern Brazil flora have been assayed against epimastigote forms of Trypanosoma cruzi, using the tetrazolium salt MTT as an alternative method. Eight compounds belonging to four different species: Harpalyce brasiliana (Fabaceae), Acnistus arborescens and Physalis angulata (Solanaceae), and Cordia globosa (Boraginaceae) showed significant activity. Among them, a novel and a known pterocarpan, a chalcone, four withasteroids, and a meroterpene benzoquinone were the represented chemical classes.

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http://dx.doi.org/10.1016/j.bmc.2007.11.027DOI Listing

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