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Ex Vivo Fungal Nail Penetration Study: Effects of Causative Organisms, Nail Polish and Age.
Mycoses
January 2025
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Background: Few ex vivo studies have investigated the virulence factors of fungi causing onychomycosis. The effect of nail polish in predisposing or protecting against onychomycosis remains debatable.
Objectives: This ex vivo study aimed to identify the nail invasion ability of dermatophytes, non-dermatophytes and yeast, with and without nail polishing, in the nails of young and elderly individuals.
Comparison of dermoscopic characteristics on toenail onychomycosis in psoriatic and non-psoriatic patients: A prospective study.
Mycoses
April 2024
Department of Dermatology, Peking University First Hospital, Beijing, China.
Article Synopsis
- Psoriatic patients often have onychomycosis (OM), but evaluating it in them is complicated due to possible differences from non-psoriatic cases.
- This study examined the dermoscopic features of toenail OM in 183 psoriatic patients compared to 232 non-psoriatic patients from 2020 to 2023, revealing significant differences in appearance.
- Results showed psoriatic toenail OM had more pitting and periungual telangiectasis, while non-psoriatic cases had features like nail spikes and yellow structureless areas, indicating distinct characteristics between the two groups.
Treatment Options for Onychomycosis: Efficacy, Side Effects, Adherence, Financial Considerations, and Ethics.
J Clin Aesthet Dermatol
March 2024
Drs. Yousefian, Smythe, Han and Nestor are with the Center for Clinical and Cosmetic Research in Aventura, Florida.
Background: Onychomycosis is a fungal infection of the nail unit that affects a large patient population globally. Onychomycosis, or tinea unguium, has a benign chronic clinical course; however, it can cause complications in certain patient populations suffering from diabetes and peripheral vascular disease. As nails grow slowly, onychomycosis requires a lengthy treatment plan, and choosing appropriate treatments can be challenging.
View Article and Find Full Text PDFSafety assessment for nail cosmetics: Framework for the estimation of systemic exposure through the nail plate.
Regul Toxicol Pharmacol
March 2024
Wella Company, Berliner Allee 65, 64295, Darmstadt, Germany. Electronic address:
All cosmetics products, including nail care products, must be evaluated for their safety. The assessment of systemic exposure is a key component of the safety assessment. However, data on the exposure, especially via ungual route (nail plate) are limited.
View Article and Find Full Text PDFNail psoriasis in China: A prospective multicentre study.
J Eur Acad Dermatol Venereol
March 2024
Department of Dermatology and Venereology, Peking University First Hospital, National Clinical Research Centre for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing, China.
Article Synopsis
- A study on nail psoriasis (PsO) in China involved 817 patients and aimed to gather data on epidemiology, symptoms, infections, arthritis, and treatments to improve patient care worldwide.
- The majority of patients were male (71.41%), with high involvement in fingernails (95.29%) and significant manifestations like pitting (67.11%) and hyperkeratosis (60.40%).
- Despite the severity of symptoms, only a small number (2.30%) received treatment, with biologic therapy being the most common for those with skin psoriasis that also affected their nails.*
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