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Clinical studies in Myxomatous Mitral Valve Disease dogs: most prescribed ACEI inhibits ACE2 enzyme activity and ARB increases AngII pool in plasma.
Hypertens Res
January 2025
Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
The hypertension patient population has doubled since 1990, affecting 1.3 billion globally and >75% live in low-and middle-income countries. Angiotensin Converting Enzyme Inhibitors (ACEI) and Angiotensin Receptor Blockers (ARB) are the most prescribed drugs (>160 million times in the US), but mortality increased >30% since 1990s globally.
View Article and Find Full Text PDFRedescription of Oshmarin & Demshin, 1972 (Heterakidae: Meteterakinae) from a geoemydid tortoise in China with comments on the genus.
J Helminthol
December 2024
A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii prospect 33, Moscow, 119071, Russian Federation.
Oshmarin & Demshin, 1972 is redescribed from the posterior intestine of tropical tortoise (Gmelin, 1789) (Testudines: Geoemydidae) from China. Some characteristic features of the male reproductive system not reported previously are now reported for the present species. These include the presence of two blind diverticula near the mid-region of the seminal vesicle and a small cuticular structure near the opening of the cloaca - which we propose to name the 'scutum.
View Article and Find Full Text PDFDietary Phytic Acid, Dephytinization, and Phytase Supplementation Alter Trace Element Bioavailability-A Narrative Review of Human Interventions.
Nutrients
November 2024
Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, 42100 Trikala, Greece.
Background: Phytic acid is abundant in plant-based diets and acts as a micronutrient inhibitor for humans and non-ruminant animals. Phytases are enzymes that break down phytic acid, releasing micronutrients and enhancing their bioavailability, particularly iron and zinc. Deficiencies in iron and zinc are significant public health problems, especially among populations with disease-associated malnutrition or those in developing countries consuming phytic acid-rich diets.
View Article and Find Full Text PDFRelationship Between Serum Vitamin D Levels and Chronic Musculoskeletal Pain in Adults: A Systematic Review.
Nutrients
November 2024
Department of Physiotherapy, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, Spain.
Background/objectives: Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D's critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results.
Methods: This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain.
Optimizing transport methods to preserve function of self-innervating muscle cells for laryngeal injection.
Laryngoscope Investig Otolaryngol
December 2024
Indiana University School of Medicine (IUSM) Indianapolis Indiana USA.
Objectives: Recently, our laboratory has discovered a self-innervating population of muscle cells, called motor endplate-expressing cells (MEEs). The cells innately release a wide variety of neurotrophic factors into the microenvironment promoting innervation when used as an injectable treatment. Unlike other stem cells, the therapeutic potential of MEEs is dependent on the cells' ability to maintain phenotypical cell surface proteins in particular motor endplates (MEPs).
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