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The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions.
DNA Repair (Amst)
December 2024
Agriculture and Marine Science Program, Graduate School of Integrated Arts and Science, Kochi University, Nankoku, Kochi 783-8502, Japan; Agricultural Science, Graduate School of Integrated Arts and Science, Kochi University, Nankoku, Kochi 783-8502, Japan. Electronic address:
Most giant viruses including Mimiviridae family build large viral factories within the host cytoplasms. These giant viruses are presumed to possess specific genes that enable the rapid and massive replication of their large double-stranded DNA genomes within viral factories. It has been revealed that a functionally uncharacterized protein, MutS7, is expressed during the operational phase of the viral factory.
View Article and Find Full Text PDFLarge Douglas Abscess with Distinctive Bilateral Salpingitis in a Young Virginal Woman 6 Months Following Small Bowel Perforation at the Level of the Jejunojejunostomy After Roux-en-Y Gastric Bypass: A Case Report.
Int J Womens Health
December 2024
Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Lucerne, 6000, Switzerland.
Douglas abscesses (DA) involving the ovaries and/or fallopian tubes and tubo-ovarian abscesses (TOA) constitute a very rare finding in virginal females. Underlying conditions are suspected to play a role in their development; often however, the exact pathomechanism remains hypothetical or unknown. We report the case of a 19-year-old virginal female who was referred to our outpatient clinic for further clarification of a 6-month ongoing secondary amenorrhea.
View Article and Find Full Text PDFCurrent state of epigenetics in giant cell arteritis: Focus on microRNA dysregulation.
Autoimmun Rev
December 2024
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address:
Giant cell arteritis (GCA) is a primary systemic vasculitis affecting the elderly, characterized by a granulomatous vessel wall inflammation of large- and medium-sized arteries. The immunopathology of GCA is complex, involving both the innate and adaptive arms of the immune system, where a maladaptive inflammatory-driven vascular repair process ultimately results in vessel wall thickening, intramural vascular smooth muscle cell proliferation, neovascularization and vessel lumen occlusion, which can lead to serious ischemic complications such as visual loss and ischemic stroke. Over the past decade, microRNA (miRNA) dysregulation has been highlighted as an important contributing factor underlying the pathogenesis of GCA.
View Article and Find Full Text PDFGiant Primary Cutaneous Nodular Melanoma of the Forehead: A Case Report.
Geriatrics (Basel)
December 2024
Medicine for Older People, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.
The incidence of melanoma is increasing globally. The estimated worldwide incidence is projected to increase from 324,635 cases in 2020 to 510,000 in 2040. In the UK, melanoma accounts for 4% of all new cases of cancer.
View Article and Find Full Text PDFNonadjustable state of programmable shunt valve: obstruction of middle cranial fossa arachnoid cyst-peritoneal shunt.
Chin Neurosurg J
December 2024
Department of Neurosurgery, Hebei Children's Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
Background: A nonadjustable state of the programmable shunt valve is a rare phenomenon. This case report aims to explore the cause of pressure adjustment dysfunction in a programmable shunt valve in a middle cranial fossa arachnoid cyst-peritoneal shunt patient and to underscore this dysfunction as an indicator of shunt valve obstruction.
Case Presentation: A child with a ruptured giant arachnoid cyst in the left middle cranial fossa presented with acute intracranial hypertension following head trauma.
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