AI Article Synopsis
- The study introduces a straightforward method for creating cyclic amines through chlorinating amino alcohols using thionyl chloride (SOCl2).
- This new technique simplifies the process by eliminating the traditional multi-step sequence, which typically involves protecting and activating groups before cyclization and then removing them.
- The research also explores the various reaction pathways and the broader applicability of this method in transforming amino alcohols into cyclic amines.
Article Abstract
A simple, one-pot preparation of cyclic amines via efficient chlorination of amino alcohols with use of SOCl(2) has been developed. This approach obviates the need for the classical N-protection/O-activation/cyclization/deprotection sequence commonly employed for this type of transformation. The reaction pathways and the general scope of this method have also been investigated.
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| http://dx.doi.org/10.1021/jo701877h | DOI Listing |
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