AI Article Synopsis
- Ulocladium atrum Preuss shows promise as a biological control agent against the plant pathogen Botrytis cinerea in crops.
- An antibiotic peptide was isolated from U. atrum, characterized as a cyclopeptolide with many N-methylated amino acids, using detailed spectroscopic analyses.
- The isolated compound demonstrated strong antifungal activity against Botrytis cinerea and moderate activity against other fungi like Alternaria alternate and Magnaporthe grisea.
Article Abstract
The saprophytic fungus Ulocladium atrum Preuss is a promising biological control agent for Botrytis cinerea in greenhouse- and field-grown crops. However, despite its known potent antifungal activity, no antifungal substance has yet been reported. In an effort to characterize the antifungal substance from U atrum, we isolated an antibiotic peptide. Based on extensive spectroscopic analyses, its structure was established as a cyclopeptolide with a high portion of N-methylated amino acids, and its 1H and 13C chemical shifts were completely assigned based on extensive 1D and 2D NMR experiments. Compound 1 exhibited potent antifungal activity against the plant pathogenic fungus Botrytis cinerea and moderate activity against Alternaria alternate and Magnaporthe grisea.
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