AI Article Synopsis
- The report focuses on two HBV clones from a patient with hepatocellular carcinoma, highlighting one with a preC mutation (1896A) and the other without.
- There was a significant difference in mutation frequency in the Core region among four open reading frames (ORFs) between the two strains.
- The findings suggest that mutations may contribute to HBV persistence and hepatocarcinogenesis, particularly in Korean HBV strains that are part of genotype C2.
Article Abstract
This report describes the full-length sequences of 2 HBV clones from a hepatocellular carcinoma (HCC) patient, one with preC mutation (1896A) and the other without preC mutation. The high level of discrepancy in mutation frequency between these 2 strains was observed in the Core (C) region among 4 ORFs. These data support previous results that Korean HBV strains, belonging to genotype C2, are prone to mutations. It is possible that the mutations (BCP and preC mutations) associated with the HBeAg defective production might contribute to the diversity of mutations related to HBV persistence, playing an important role in hepatocarcinogenesis in this patient.
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