Germ cell cancer is the most common malignancy in men 15-35 years of age; 5% of malignant germ cell tumors are of extragonadal origin. The key to diagnosis and management is tumor histology. This point is highlighted in this case review. It also reinforces that germ cell tumor markers should be done in all young patients diagnosed with malignancy. We describe the case of a 21-year-old man who was diagnosed as having inoperable cancer of the ascending colon, which turned out to be extragonadal germ cell tumor after studies. This patient has responded very well to bleomycin, etoposide, and cisplatin chemotherapy.
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