AI Article Synopsis
- The study aims to explore microstructural changes in the brains of Alzheimer's disease patients using diffusion tensor imaging (DTI), focusing on mean diffusivity (MD) and fractional anisotropy (FA).
- In a comparison of 13 Alzheimer's patients and 13 control participants, significant increases in MD were found in key brain areas associated with memory and cognition, while FA showed reductions in regions connected to thalamic pathways.
- The results suggest that advanced DTI analysis can effectively identify structural brain changes in Alzheimer's disease, contributing to our understanding of the disease's impact on brain function.
Article Abstract
Purpose: To investigate microstructural changes in cortical and white matter pathways in patients with Alzheimer's disease using diffusion tensor imaging (DTI).
Materials And Methods: Measures of mean diffusivity (MD) and fractional anisotropy (FA) were compared in the brains of 13 Alzheimer's disease (AD) patients and a group of 13 aged-matched control participants employing an optimized DTI technique involving a fully automated, voxel-based morphometric (VBM) analysis.
Results: After rigorous control for anatomical variation and confounding partial volume effects, we found significantly elevated MD measures within the hippocampus, amygdala, and medial temporal, parietal, and frontal lobe gray matter regions in the AD participants. The largest number of pixels with increased MD was localized bilaterally, within the posterior cingulate gyrus. The FA was significantly reduced within the thalamus, parietal white matter, and posterior limbs of the internal capsule, indicating significant involvement of corticothalamic and thalamocortical radiations.
Conclusion: This study demonstrates that rigorous VBM analysis of DTI data can be used to investigate microstructural changes in cortical, subcortical, and white matter regions in AD.
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| http://dx.doi.org/10.1002/jmri.21231 | DOI Listing |
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