Plasmacytoid dendritic cells (pDC) specialize in the secretion of type I interferon (IFN). Although multiple pathways that modulate type I IFN responses have been described they are inadequately defined. In this issue of the European Journal of Immunology, evidence for a B cell receptor (BCR)-like signaling cascade in pDC that suppresses type I IFN production is provided.
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| http://dx.doi.org/10.1002/eji.200737944 | DOI Listing |
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