Objective: Research demonstrates that interventions targeting multiple settings within a child's life are more effective in treating or preventing conduct disorder. One such program is the Incredible Years Series, which comprises three treatment components, each focused on a different context and type of daily social interaction that a child encounters. This article explores the cost-effectiveness of stacking multiple intervention components versus delivering single intervention components.
Method: The data involved 459 children, ages 3 to 8, who participated in clinical trials of the Incredible Years Series. Children randomized to one of six treatment conditions received one or more of the three following program components: a child-based program, a parent training program, and a teacher-based program instructing teachers in classroom management and in the delivery of a classroom-based social skills curriculum.
Results: Per-child treatment costs and child behavior outcomes (observer and teacher reported) were used to generate cost-effectiveness acceptability curves; results suggest that stacking intervention components is likely cost-effective, at least for willingness to pay above $3,000 per child treated.
Conclusions: Economic data may be used to compare competing intervention formats. In the case of this program, providing multiple intervention components was cost-effective.
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http://dx.doi.org/10.1097/chi.0b013e3181514c8a | DOI Listing |
Appl Microbiol Biotechnol
January 2025
Engineering Biology Research Center, Kobe University, 1-1 Rokkodai, Nada, Kobe, 657-8501, Japan.
The fermentative production of valuable chemicals from lignocellulosic feedstocks has attracted considerable attention. Although Saccharomyces cerevisiae is a promising microbial host, it lacks the ability to efficiently metabolize xylose, a major component of lignocellulosic feedstocks. The xylose oxidative pathway offers advantages such as simplified metabolic regulation and fewer enzymatic steps.
View Article and Find Full Text PDFPediatr Nephrol
January 2025
Department of Pediatrics, University of California San Diego, 3020 Children's Way MC 5137, San Diego, CA, 92123, USA.
Background: Inadequate treatment of acute rejection (AR) in pediatric kidney transplant recipients (KTR) can contribute to early allograft failure. Serum creatinine is an insensitive marker of allograft function, especially in the pediatric population, and may not detect ongoing rejection after treatment. We evaluated the utility of follow-up biopsies to detect persistent inflammation and future episodes of rejection.
View Article and Find Full Text PDFEnviron Toxicol Chem
January 2025
ToxStrategies, LLC, Katy, TX, USA.
A key component of ecological risk assessments is to develop evidence-based benchmarks to assess potential hazards to various receptors. To ensure that toxicity value development is performed using the best available science, the reliability (or inherent scientific quality) of these studies must be considered. The degree of reliability can be evaluated via critical appraisal tools (CATs), though application of such methods assessing ecotoxicological literature for toxicity value development is not well established compared to human health assessments.
View Article and Find Full Text PDFEur J Cardiovasc Nurs
January 2025
NHSBT Clinical Trials Unit, Unit, NHSBT CTU, Long Road, Cambridge CB2 0PT, UK.
Aims: A single-blinded, multicentred randomized controlled trial (RCT) was employed to examine the effectiveness of a 3-month telephone follow-up, a telephone follow-up with education before discharge, or education only before discharge on the heart failure (HF) knowledge, HF self-care management, and health-related quality of life (HR-QoL) in patients with HF by a nurse specialist.
Methods And Results: This is a multicentre RCT with three different intervention groups (IGs) and one control group. Participants in the first IG received education on HF self-management principles before discharge.
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