AI Article Synopsis
- A total synthesis of thromboxane B2 is achieved using an innovative approach that includes intermolecular ketalization and ring-closing metathesis.
- Key methods in this synthesis involve Sharpless asymmetric epoxidation to create an oxirane, followed by epoxide opening with lithioacetonitrile.
- Additional transformations include an allylic alcohol 1,3-transposition and Mitsunobu lactonization to finalize the synthesis.
Article Abstract
Total synthesis of thromboxane B2 using intermolecular ketalization followed by ring-closing metathesis is reported. Other key steps include a Sharpless asymmetric epoxidation to form an oxirane on the endo face of the bicyclic acetal, epoxide opening using lithioacetonitrile, an allylic alcohol 1,3-transposition, and Mitsunobu lactonization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol7021214 | DOI Listing |
Publication Analysis
Top Keywords
synthesis thromboxane
8
thromboxane ketalization/ring-closing
4
ketalization/ring-closing metathesis
4
metathesis total
4
total synthesis
4
thromboxane intermolecular
4
intermolecular ketalization
4
ketalization ring-closing
4
ring-closing metathesis
4
metathesis reported
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!