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Safety and efficacy of trifluridine/tipiracil +/- bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial.
Signal Transduct Target Ther
January 2025
Centre de Recherche INSERM Center for Translational and Molecular Medicine, 21000, Dijon, France.
In the tumour microenvironment, IL-1α promotes neoangiogenesis, matrix remodelling, tumour proliferation, chemoresistance, and metastases. Highly expressed in human colorectal cancers, IL-1α is associated with poor prognosis. XB2001, a fully human monoclonal antibody neutralizing IL-1α, was evaluated for safety and preliminary efficacy with trifluridine/tipiracil (FTD/TPI) and bevacizumab in metastatic colorectal cancer patients previously treated with oxaliplatin- and irinotecan-based chemotherapies.
View Article and Find Full Text PDFDehydroabietylamine exerts antitumor effects by affecting nucleotide metabolism in gastric cancer.
Carcinogenesis
October 2024
Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, China.
Article Synopsis
- * The study reveals that dehydroabietylamine (DHAA), a natural compound, effectively decreases the growth of gastric cancer cells by disrupting their nucleotide metabolism and inducing DNA damage.
- * DHAA targets the transcription factor FOXK2, leading to reduced expression of key metabolic enzymes, and has shown promise in delaying tumor development in a mouse model, making it a potential new treatment for gastric cancer.
Defining a timeline of colon pathologies after keratin 8 loss: rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.
Am J Physiol Gastrointest Liver Physiol
January 2024
Cell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Keratins are epithelial intermediate filament proteins that play a crucial role in cellular stress protection, with K8 being the most abundant in the colon. The intestinal epithelial-specific K8-deficient mouse model (K8;Villin-Cre) exhibits characteristics of inflammatory bowel disease, including diarrhea, crypt erosion, hyperproliferation, and decreased barrier function. Nevertheless, the order in which these events occur and whether they are a direct cause of K8 loss or a consequence of one event inducing another remains unexplored.
View Article and Find Full Text PDFThree dimensional (3D) gingival models in periodontal research: a systematic review.
J Mater Sci Mater Med
November 2023
Periodontology Unit, UCL Eastman Dental Institute, 21 University Street, London, WC1E 6DE, UK.
The aim of this study is to systematically appraise the evidence on available full thickness 3D gingival and mucosal models (3D culture in scaffold base system) and their application in periodontal and peri-implant research. This study involved a systematic review of twenty-two studies obtained from searching from five electronic databases: MEDLINE-OVID, EMBASE, EBSCOhost, Web of Science Core Collection and LILACS, as well as a hand search of eligible articles up to September 2022. A total of 2338 studies were initially identified, after removal of duplicates (573), abstracts/title selection (1765), and full text screening (95), twenty-two studies were included, thirty-seven models were identified.
View Article and Find Full Text PDFKeratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer.
BMC Mol Cell Biol
August 2023
Department of Biology, The Catholic University of America, Washington, DC, United States of America.
Article Synopsis
- HNRNPK is a protein that plays a crucial role in processing pre-mRNA and localizes to the nucleus but can move to the cytoplasm, influencing cancer growth and spread.
- The study found that Keratin 19 (K19) binds to HNRNPK, keeping it in the cytoplasm, while lacking K19 leads to HNRNPK being unable to localize there, which decreases cell proliferation in breast cancer cells.
- HNRNPK's presence in the cytoplasm enhances the stability of certain cancer-related mRNAs, particularly affecting pathways like p53 signaling, indicating the importance of K19 in regulating HNRNPK and its function in cancer progression.
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