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GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: Pre-analytical and clinical considerations.
J Mass Spectrom Adv Clin Lab
November 2023
Hannover Medical School, Institute of Toxicology, Core Unit Proteomics, 30623 Hannover, Germany.
Malondialdehyde (MDA; 1,3-propanedial, OHC-CH-CHO) is one of the most frequently measured biomarkers of oxidative stress in plasma and serum. L-Arginine (Arg) is the substrate of nitric oxide synthases (NOS), which convert L-arginine to nitric oxide (NO) and L-citrulline. The Arg/NO pathway comprises several members, including the endogenous NOS-activity inhibitor asymmetric dimethylarginine (ADMA) and its major metabolite dimethyl amine (DMA), and nitrite and nitrate, the major NO metabolites.
View Article and Find Full Text PDFN-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
Amino Acids
September 2022
Clinic for Rheumatology und Immunology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
N-Acetyl-L-cysteine (NAC) is an endogenous cysteine metabolite. The drug is widely used in chronic obstructive pulmonary disease (COPD) and as antidote in acetaminophen (paracetamol) intoxication. Currently, the utility of NAC is investigated in rheumatoid arthritis (RA), which is generally considered associated with inflammation and oxidative stress.
View Article and Find Full Text PDFHydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological Review.
Front Pharmacol
December 2020
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Article Synopsis
- Hydroxychloroquine has been considered as a potential drug for preventing COVID-19 due to its ability to inhibit SARS-CoV-2 in lab settings, but evidence from animal studies and clinical trials shows mixed results on its effectiveness.
- Issues such as inadequate drug concentrations and the effect of specific proteins in the respiratory system may contribute to its limited success in real-world applications.
- Ongoing clinical trials and safety concerns about higher doses highlight the need to explore alternative prevention strategies for high-risk populations.
Systematic review on women's values and preferences concerning breast cancer screening and diagnostic services.
Psychooncology
May 2019
Biomedical Research Institute (IIB Sant Pau), Iberoamerican Cochrane Centre, Barcelona, Spain.
Article Synopsis
- - Women's preferences are key in shaping breast cancer screening guidelines, especially given the mixed views on its benefits versus harms.
- - A systematic review of 22 studies revealed that women are willing to endure the mental and physical challenges of screening for the chance of an earlier diagnosis, despite risks of overdiagnosis and false positives.
- - There is a significant emphasis on the need for quicker testing and better communication since the delay in getting results is a major source of anxiety for women, highlighting that while they value early diagnosis, understanding the risks like overdiagnosis remains a concern.
[Clinico-Pharmacological and Clinical Basis of Multiplicity of Intake of Novel Oral Anticoagulants].
Kardiologiia
November 2017
State Budgetary Educational Institution of Advanced Professional Education, "Russian Medical Academy of Postgraduate Education" of the Ministry of Health of the Russian Federation.
In this review we present comparison of pharmacokinetics of novel oral anticoagulants (NOAC) dabigatran, rivaroxaban, apixaban, and edoxaban, principles of selection of a regimen of their dosing for phase III clinical trials in patients with atrial fibrillation. Multiplicity of administration of NOAC depends on required level of anticoagulation, ability to maintain anticoagulation for 24 hours, relationship between minimal and maximal levels of equilibrium concentrations, efficacy and safety. Once a day administration of some drugs of this group is reasonable from positions of clinical pharmacology.
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