The experiments on rats with toxic lesions of the liver induced by tetrachlorinemethane showed that parmidine (pyridinolcarbamat) promotes the reduction of the activity of lipid peroxidation in the liver tissue homogenates and erythrocytes. The pronounced tendency towards normalization of free-radical oxidation correlated with the positive dynamics of the histological picture of the liver.
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Anticancer Agents Med Chem
January 2025
Department of Biochemistry, Faculty of Science, Selcuk University, Konya, Turkiye.
Introduction/objective: Plants and their bioactive compounds play a crucial role in the pharmaceutical industry for treating cancer. To date, the cytotoxic and antiproliferative effects of Hypericum perforatum methanol extract on human thyroid cancer cell lines have not been thoroughly explored. The present study aimed to assess the potential anti-cancer effects of HPME on human thyroid cancer and investigate its potential therapeutic benefits.
View Article and Find Full Text PDFCurr Mol Med
January 2025
Department of Anesthesiology, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Background: Morphine, a mu-opioid receptor (MOR) agonist commonly utilized in clinical settings alongside chemotherapy to manage chronic pain in cancer patients, has exhibited contradictory effects on cancer, displaying specificity toward certain cancer types and doses.
Objective: The aim of this study was to conduct a systematic assessment and comparison of the impacts of morphine on three distinct cancer models in a preclinical setting.
Methods: Viability and apoptosis assays were conducted on a panel of cancer cell lines following treatment with morphine, chemotherapy drugs alone, or their combination.
World J Diabetes
January 2025
Department of Nephrology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.
Background: Mizagliflozin (MIZ) is a specific inhibitor of sodium-glucose cotransport protein 1 (SGLT1) originally developed as a medication for diabetes.
Aim: To explore the impact of MIZ on diabetic nephropathy (DN).
Methods: Diabetic mice were created using db/db mice.
MycoKeys
January 2025
Hainan Academy of Forestry (Hainan Academy of Mangrove), Haikou, 571100, China Hainan Academy of Forestry (Hainan Academy of Mangrove) Haikou China.
is a large and complex genus of macrofungi, playing a critical role in ecosystems as decomposers and possessing antimicrobial, anticancer, and antioxidant properties. This paper described two new species discovered on fallen leaves in Hainan Tropical Rainforest National Park, based on morphological characteristics and genetic sequences. Detailed color illustrations and comparisons with similar species were provided.
View Article and Find Full Text PDFVet Anim Sci
March 2025
Animal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran.
This study aims to measure the effects of different dietary concentrations of triticale hay (TH) on productive performance, carcass characteristics, microbial protein synthesis (MPS), ruminal and blood variables, and antioxidant power in 40 fattening male Gray Shirazi lambs (BW of 33.2 ± 1.1 kg) over 81 days in a completely randomized design (10 animals/diet).
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