Pharmacological treatment of cerebrovascular disorders was introduced at the beginning of the 20th Century. Since then, a multitude of studies have focused on the development of a consensus for a well defined taxonomy of these disorders and on the identification of specific patterns of cognitive deficits associated with them, but with no clear consensus. Nevertheless, citicoline has proved to be a valid treatment in patients with a cerebrovascular pathogenesis for memory disorders. A metanalysis performed on the entire database available from the clinical studies performed with this compound confirms the experimental evidence from the animal studies which have repeatedly described the multiple biological actions of citicoline in restoring both the cell lipid structures and some neurotransmitter functions.
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| http://dx.doi.org/10.2147/ciia.2006.1.3.247 | DOI Listing |
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Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
J Nutr
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Research & Innovation Center, Kyowa Hakko Bio Co., Ltd, Tsukuba, Ibaraki, 305-0841, Japan.
Background: Supplementation of citicoline (CDP-choline), a naturally occurring mononucleotide, has shown beneficial effects on memory function and behavior in populations with a wide range of impairments. However, few studies have investigated its effect in healthy older populations.
Objective: The objective of this study was to investigate the effects of citicoline (Cognizin®), on memory in healthy elderly populations with age-associated memory impairment (AAMI).
The Effect of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males.
J Atten Disord
January 2019
1 University of Utah, Salt Lake City, UT, USA.
Objective: This study assessed the effects of citicoline, a nutraceutical, on attention, psychomotor function, and impulsivity in healthy adolescent males.
Method: Seventy-five healthy adolescent males were randomly assigned to either the citicoline group ( n = 51 with 250 or 500 mg citicoline) or placebo ( n = 24). Participants completed the Ruff 2&7 Selective Attention Test, Finger Tap Test, and the Computerized Performance Test, Second Edition (CPT-II) at baseline and after 28 days of supplementation.
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Objective: Cytidine-5'-diphosphocholine (citicoline) has a variety of cognitive enhancing, neuroprotective, and neuroregenerative properties. In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown.
View Article and Find Full Text PDFCiticoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy.
NMR Biomed
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Cognitive Neuroimaging Laboratory, McLean Hospital & Harvard Medical School, 115 Mill Street, Belmont, MA 02478-9106, USA.
Article Synopsis
- Citicoline supplementation has been studied for its potential benefits in memory improvement for older adults and those with Alzheimer's disease.
- A study utilized magnetic resonance spectroscopy (MRS) to analyze the effects of different doses of citicoline on brain metabolites over six weeks in healthy participants, revealing significant increases in energy-related compounds in the frontal lobe.
- Findings suggest that citicoline enhances brain energy reserves and alters phospholipid turnover, potentially helping to counter cognitive decline linked to aging.
Citicoline (Cognizin) in the treatment of cognitive impairment.
Clin Interv Aging
January 2008
Department of Psychiatric Science and Psychological Medicine, University of Rome La Sapienza, Rome, Italy.
Pharmacological treatment of cerebrovascular disorders was introduced at the beginning of the 20th Century. Since then, a multitude of studies have focused on the development of a consensus for a well defined taxonomy of these disorders and on the identification of specific patterns of cognitive deficits associated with them, but with no clear consensus. Nevertheless, citicoline has proved to be a valid treatment in patients with a cerebrovascular pathogenesis for memory disorders.
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