Recent evidence suggests that platelet activation and angiotensin II may each contribute to glomerular inflammation and fibrosis. Clopidogrel inhibits platelet activation and may also reduce inflammation. This study investigated the anti-inflammatory and renoprotective effects of clopidogrel and irbesartan in the five-sixths nephrectomy rat model of chronic kidney disease. After 8 wk of treatment, 24-h proteinuria, serum creatinine, and histologic scores of glomerular sclerosis and tubulointerstitial damage were significantly lower in treated compared with untreated rats. Clopidogrel/irbesartan combination therapy had greater effects than either drug alone. Rats that underwent five-sixths nephrectomy had higher markers of platelet activation (plasma GMP-140 and renal cortical fibrin deposition) than sham-operated rats, and clopidogrel attenuated these effects. Clopidogrel and irbesartan similarly reduced the accumulation of ED-1-expressing macrophages in the cortical glomeruli and the interstitium. Combination therapy almost completely abolished macrophage infiltration and attenuated the expression of monocyte chemoattractant protein-1, intercellular adhesion molecule-1, TGF-beta(1), and connective tissue growth factor. In conclusion, combination treatment with clopidogrel and irbesartan, more so than either alone, decreases early renal injury induced by five-sixths nephrectomy by inhibiting renal inflammation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2391039 | PMC |
| http://dx.doi.org/10.1681/ASN.2007020160 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation.
Circulation
October 2024
Department of Medical Sciences, Neurology (K.S., J.B.)Uppsala University, Sweden.
Background: Biomarkers reflecting brain injury are not routinely used in risk assessment of stroke in atrial fibrillation (AF). Neurofilament light chain (NFL) is a novel biomarker released into blood after cerebral insults. We investigated the association between plasma concentrations of NFL, other biomarkers, and risk of stroke and death in patients with AF not receiving oral anticoagulation.
View Article and Find Full Text PDFObservation on the Efficacy of Ketone Ester Drop Pill in Improving Hypertension Combined with Carotid Atherosclerotic Plaque.
Emerg Med Int
June 2022
Department of Neurology, Ningbo Hospital of Traditional Chinese Medicine, Ningbo 315000, Zhejiang, China.
Purpose: To observe and analyze the efficacy of ketone ester drop pill intervention in patients with hypertension combined with carotid atherosclerotic plaque.
Methods: The subjects were 300 patients with hypertension complicated with carotid atherosclerotic plaque treated in our hospital from January 2019 to September 2021. The grouping was done by the random number table method and 300 patients were divided equally into 2 groups.
Predictors of Mortality in Patients With Atrial Fibrillation (from the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events [ACTIVE A]).
Am J Cardiol
March 2018
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. Electronic address:
The mortality rate of most patients with atrial fibrillation (AF) exceeds the stroke rate, but predictors of mortality have not been well defined. The Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE A) recruited patients with AF who were unsuitable to receive vitamin K-antagonists and were randomized to aspirin alone versus aspirin plus clopidogrel. We investigated independent predictors of all-cause mortality by multivariable Cox regression analysis and explored interactions with assigned antiplatelet therapy.
View Article and Find Full Text PDFRelationship between degree of left ventricular dysfunction, symptom status, and risk of embolic events in patients with atrial fibrillation and heart failure.
Stroke
March 2015
From the Division of Cardiology, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada (R.K.S.); Division of Cardiac Electrophysiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Division of Cardiology, Brigham and Women's Hospital, Harvard University, Boston, MA (M.A.P.); Division of Neurology (R.G.H.), Division of Cardiology (S.Y., S.J.C., J.S.H.), Population Health Research Institute (F.Y.), McMaster University, Hamilton, ON, Canada; The Canadian VIGOUR Center, Edmonton, Alberta, Canada (F.A.M.); and Division of General Internal Medicine, University of Alberta, Edmonton, Canada (F.A.M.).
Background And Purpose: Limited data exists regarding the relationship between left ventricular systolic dysfunction (LVSD) and heart failure (HF) symptoms and embolic risk among patients with atrial fibrillation.
Methods: Participants in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE) trials with HF, but not randomized to oral anticoagulation, were categorized as having preserved versus reduced ejection fraction. If reduced, LVSD was classified as mild, moderate, or severe.
[AII antagonists (candesartan and irbesartan) in the treatment of cardiovascular diseases].
Vnitr Lek
October 2012
Interní kardiologická klinika Lékarské fakulty MU a FN Brno, pracoviste Bohunnice.
Treatment of hypertension with angiotensin II receptor antagonists (AIIA) was first limited to diabetics and patients with microalbuminuria. So far, results of several large clinical trials with AIIAs were published, confirming significant renoprotective effect of these agents compared to placebo (RENAAL and IRMA), amlodipin (MARVAL and IDNT) and a combination of ACEI and AIIA (CALM). In 2002, results of 2 large comparator studies in hypertension were published: LIFE - Losartan Intervention For Endpoints and SCOPE - the Study on COgnition and Prognosis in Elderly hypertensives.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!