The effect on the pulp-dentin system by chlorhexidine 0.2% in comparison to the physiological sodium chloride solution was investigated in animal experiments. The methods of tests were based on the requirements of FDI 1980. After 3, 21, 70 and 90 days the teeth were extracted and prepared for histological studies. The evaluation of the histological preparations including measurement on the residual dentin layer was achieved by light microscopy. Differences in the pulp reaction after treatment of the teeth with chlorhexidine or sodium chloride solution could not be observed. The changes of pulp tissue were slight to moderate and depended on the residual dentin layer. The cavity cleaning with chlorhexidine 0.2% did not cause any additional damage in the pulp.
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