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miRNA Expression: I/R Cardiomyocyte and Sevoflurane.
Biomolecules
December 2024
Department of Anesthesiology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain.
Background: The effects of anesthetic drugs on myocardial cells have been a subject of research for the last 50 years. The clinical benefits of halogenated agents, particularly sevoflurane, have been demonstrated in cardiac surgery patients. These benefits are due to the action of different enzymes and a variety of molecular pathways mediated by the action of small noncoding RNAs (sRNA) such as microRNAs (miRNAs).
View Article and Find Full Text PDFAssessment of the antinociceptive effect of a single fentanyl bolus dose in children: A pharmacokinetic and pharmacodynamic analysis based on the nociception level index during sevoflurane general anesthesia.
Paediatr Anaesth
December 2024
División de Anestesiología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Article Synopsis
- The Nociception Level Index is a tool that helps doctors understand pain balance in kids, but it hasn't been tested much before.
- The study looked at how well the Nociception Level Index works to track pain and the effect of fentanyl (a pain medicine) in kids getting certain surgeries.
- Nineteen children were tested, and results showed that fentanyl helped lower pain levels after it was given, but pain signs returned to higher levels after a while.
Relationship between intraoperative requirement for anesthetics and postoperative analgesic consumption in laparoscopic colectomy: a randomized controlled double-blinded study.
Anesth Pain Med (Seoul)
April 2024
Department of Anesthesiology and Pain Medicine, Jeonbuk National University Medical School and Hospital, Jeonju, Korea.
Background: This study investigated the relationship between intraoperative requirement for an inhalational anesthetic (sevoflurane) or an opioid (remifentanil) and postoperative analgesic consumption.
Methods: The study included 200 adult patients undergoing elective laparoscopic colectomy. In the sevoflurane group, the effect-site concentration of remifentanil was fixed at 1.
Lidocaine effects on neutrophil extracellular trapping and angiogenesis biomarkers in postoperative breast cancer patients with different anesthesia methods: a prospective, randomized trial.
BMC Anesthesiol
April 2024
Department of Anaesthesia and Perioperative Medicine, Cancer Hospital, General Hospital of Ningxia Medical University, No.804 Shengli South Street Xingqing District, Yinchuan, 750004, Ningxia, China.
Background: Anesthesia techniques and drug selection may influence tumor recurrence and metastasis. Neutrophil extracellular trapping (NETosis), an immunological process, has been linked to an increased susceptibility to metastasis in individuals with tumors. Furthermore, recurrence may be associated with vascular endothelial growth factor A (VEGF-A), a mediator of angiogenesis.
View Article and Find Full Text PDFPrediction of blood pressure changes during surgical incision using the minimum evoked current of vascular stiffness value under sevoflurane anesthesia.
Sci Rep
November 2023
Department of Anesthesiology and Critical Care, Hiroshima University Hospital, 1-2-3 Kasumi, Minami, Hiroshima, 734-8551, Japan.
Article Synopsis
- Safe and stable anesthesia requires proper opioid administration, but individual sensitivity varies.
- The study explored the minimum evoked current of vascular stiffness (MEC) as a predictor of sympathetic responses during sevoflurane anesthesia, similar to previous findings with propofol.
- A strong correlation was found between MEC and the rate of change in systolic blood pressure during surgery, indicating that MEC can effectively predict responses under both types of anesthesia.
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