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Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy.
J Pharm Health Care Sci
January 2025
Laboratory of Clinical Pharmacy Education, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Background: Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both clinical and economic outcomes are limited. This study aimed to assess the effect of introducing an antimicrobial formulary at Yokohama City University Hospital on antibiotic usage and treatment outcomes in intra-abdominal infections.
View Article and Find Full Text PDFMaintaining operability at a high personal cost - a mixed method study on maternal healthcare workers' experiences during the COVID-19 pandemic.
BMC Health Serv Res
January 2025
Institute of Health and Care Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Introduction: The COVID-19 pandemic forced leaders and employees in health care services to take difficult decisions to manage risks associated with employee health and the organizations' functioning. This study aims to identify the changes in employee working routines, job demands, and job resources within Swedish maternal healthcare during the COVID-19 pandemic, and how these changes affected workload and health.
Methods: Data were derived from the longitudinal COPE Staff study involving midwives and physicians within maternal healthcare.
Effect of anterior chamber depth on corneal endothelium following phacoemulsification among patients with different axial lengths.
Int Ophthalmol
January 2025
Ophthalmology Department, Faculty of Medicine - Suez Canal University Hospitals, 4.5 Kilo - Ring Road, Ismailia, 41522, Egypt.
Purpose: To assess the effect of anterior chamber depth on corneal endothelium using specular microscopy following uneventful phacoemulsification among cataract patients with different axial lengths.
Methods: The study was conducted in a quasi-experimental design including 300 eyes of 300 patients with grade three age-related nuclear cataract distributed equally based on their axial length into three equal groups. All eyes had grade three nuclear cataract.
Circadian clockwork controls the balance between mitochondrial turnover and dynamics: What is life … without time marking?
Biochim Biophys Acta Bioenerg
January 2025
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. Electronic address:
Circadian rhythms driven by biological clocks regulate physiological processes in all living organisms by anticipating daily geophysical changes, thus enhancing environmental adaptation. Time-resolved serial multi-omic analyses in vivo, ex vivo, and in synchronized cell cultures have revealed rhythmic changes in the transcriptome, proteome, and metabolome, involving up to 50 % of the mammalian genome. Mitochondrial oxidative metabolism is central to cellular bioenergetics, and many nuclear genes encoding mitochondrial proteins exhibit both circadian and ultradian oscillatory expression.
View Article and Find Full Text PDFPrecise morphology control of all-organic core-shell droplets for synthesis of microencapsulated phase change materials through AC electric fields.
J Colloid Interface Sci
January 2025
National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics, Research Institute of Aero-Engine, Beihang University, Beijing 100191, China. Electronic address:
Hypothesis: Complex emulsions usually consist of aqueous phases, like oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w), serving foundational roles in colloid science. Oil-in-oil-oil (o/o/o) emulsions offer new avenues for non-aqueous reagents but face challenges in balancing the forces between multiple organic phases.
Experiments: In this work, we generate o/o/o emulsions by integrating an AC electric field with a double cross-junction microchannel.
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