Breast reduction is effective in treating symptomatic macromastia. Access to surgery is sometimes limited for overweight and obese women for fear of complications. We studied the impact of body weight on postoperative complications in a consecutive series of 273 Finnish women who underwent breast reduction using either superior pedicle (n=94) or inferior pedicle (n=175) techniques; 78% of the patients were overweight (body mass index>25). An inferiorly based pedicle was preferred in obese and big-breasted patients (P<0.001), and the mean amount of resection per breast was greater using the inferior 2 pedicle technique (888 g vs 431 g with superior pedicle technique, P<0.001). Postoperative complications were frequent (52%) but overall complication rate did not correlate with body weight, body mass index, age, surgical technique or surgeon's experience (consultant vs senior registrar). The most common complication was delayed healing due to superficial infection (26%), skin necrosis or wound dehiscence (18%), followed by deep infection (8%) and seroma formation (8%). In obese patients, areola necrosis was more frequent than in patients with normal weight (6% vs 0%, P=0.007). The amount of resection and the distance between clavicle and areola were also associated with a risk of areola necrosis (P<0.05). Seromas were more frequent after superior pedicle than after inferior pedicle reduction (14% vs 5%, P=0.019). The use of antibiotics did not affect the infection risk. Surgical revisions were needed in 23% of the patients, for delayed healing (8.8%), haemorrhage (4.0%), deep infection (1.1%) and scars or puckers (13%). Reoperations were more frequent after operations performed by senior registrars (34% vs 16%, P=0.001). Our results indicate that obesity does not increase the complication risk in breast reduction surgery to the extent that access to reduction mammaplasty should be restricted based solely on body mass index.
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http://dx.doi.org/10.1016/j.bjps.2007.10.043 | DOI Listing |
Breast Cancer
January 2025
Advanced Cancer Translational Research Institute, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Antibody-drug conjugates (ADCs) are an emerging class of anticancer therapy that combines the specificity and long circulation half-life of monoclonal antibodies with the cytotoxic potency of the payload connected through a chemical linker. The optimal management of toxicities is crucial for improving quality of life in patients undergoing ADCs and for avoiding improper dose reductions or discontinuations. This article focuses on the characteristics and management of nausea and vomiting (NV) induced by three ADCs: trastuzumab deruxtecan (T-DXd), sacituzumab govitecan (SG), and datopotamab deruxtecan (Dato-DXd).
View Article and Find Full Text PDFSwiss Med Wkly
January 2025
Department of Plastic, Reconstructive and Aesthetic Surgery, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland.
Background: Patients with symptomatic breast hypertrophy typically suffer from chronic back pain, recurrent skin irritation at the inframammary fold and/or low self-esteem resulting in impaired quality of life. Reduction mammaplasty has been shown to effectively treat symptomatic breast hypertrophy with high patient satisfaction. Despite the obvious benefits, reimbursement requests for reduction mammaplasty are initially often refused by the patient's health insurance company, thereby frequently resulting in additional examinations and eventually extra expenses.
View Article and Find Full Text PDFIran J Basic Med Sci
January 2025
Graduate school, Shenyang Medical College, Shenyang. No. 146, Huanghe North Street, Shenyang, People's Republic of China.
Objectives: Particulate matter 2.5 (PM2.5), particles with an aerodynamic diameter less than 2.
View Article and Find Full Text PDFCureus
January 2025
Department of Breast Surgery, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, JPN.
We present a case of a 46-year-old woman with recurrent breast abscess resistant to conventional treatments. Initial diagnosis of mastitis led to antibiotic therapy; however, abscess formation recurred. Subsequent interventions, including incision, drainage, and various antibiotics, were insufficient because of recurrent infections.
View Article and Find Full Text PDFANZ J Surg
January 2025
General Surgery, Blacktown and Mount Druitt Hospitals, Sydney, New South Wales, Australia.
Background: The clinical management of the axilla in early breast cancer has changed since the Z0011 trial, which showed that axillary lymph node dissection (ALND) is not necessary in select patients with a positive sentinel lymph node biopsy (SLNB). Studies have shown a significant decrease in the rates of completion ALND (cALND) since Z0011. The aims of this study were to investigate the effect of the Z0011 trial on the management of positive axillary sentinel nodes and the trends in axillary surgical management since 2005 in Australia and New Zealand.
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