Purpose: We assessed the diagnostic value of whole body magnetic resonance (MR) imaging (WB-MRI) using diffusion-weighted images (DWI) for detecting bone metastasis and compared it with that of skeletal scintigraphy (SS).
Materials And Methods: Thirty patients with malignancies (breast cancer, 17 patients; prostate cancer, 9; and one patient each, thyroid cancer, liposarcoma, leiomyosarcoma, and extraskeletal Ewing sarcoma) underwent both WB-MRI and SS to detect bone metastasis. All patients were followed more than 6 months by MR imaging, SS, or computed tomographic (CT) examination. For WB-MRI, patients were placed in feet-first supine position with table-top extender and quadrature body coil. We acquired DWI (axial plane from lower neck to proximal femur) (single shot short TI inversion-recovery [STIR]: repetition time [TR] 6243/echo time [TE] 59/inversion time [TI] 180 ms; b value: 600 s/mm(2); 5-mm slice thickness; 112 x 112 matrix), T(1)-weighted fast spin echo (T(1)WI), and STIR (sagittal plane of total spine images and coronal plane of whole body images) images. Four blinded readers independently and separately interpreted images of combined MR sequences of T(1)WI+STIR (session 1) and T(1)WI+STIR+DWI (session 2).
Results: In 10 of 30 patients, we detected a total of 52 metastatic bone lesions; in the other 20, follow-up examinations confirmed no metastatic bone lesions. For these 52 lesions, for session 2, the mean sensitivity was 96% and the positive predictive value (PPV) was 98%. Those values were superior to those of session 1 (sensitivity: 88%; PPV: 95%) and those of SS (sensitivity: 96%; PPV: 94%).
Conclusion: WB-MRI that included DWI was useful for detecting bone metastasis.
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http://dx.doi.org/10.2463/mrms.6.147 | DOI Listing |
Skeletal Radiol
January 2025
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, Korea.
Objective: To evaluate the effectiveness and safety of radiofrequency ablation (RFA) for the treatment of symptomatic distant metastasis of differentiated thyroid carcinoma.
Materials And Methods: The medical records of 12 patients who underwent RFA for the palliative treatment of 18 symptomatic distant metastases from thyroid cancer between January 2008 and December 2020 were analyzed. All patients were assessed for their degree of discomfort and underwent periodical evaluations as outpatients, including clinical examination, imaging, and serologic markers.
Cancer Discov
January 2025
Icahn School of Medicine at Mount Sinai, New York, United States.
Bone metastases can disseminate to secondary sites and promote breast cancer progression creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction power of Her2-expressing (Her2E) circulating tumor cells (CTCs) after analyzing over 13,000 CTCs from a cohort of 137 metastatic breast cancer (MBC) patients with initial HR+/Her2- status and employ preclinical models of bone metastasis (BM) to validate the role of Her2E CTCs in multi-organ metastases.
View Article and Find Full Text PDFJ Vet Dent
January 2025
Department of Dentistry, Oral and Maxillo-facial Surgery, Eastcott Veterinary Referrals, Part of Linnaeus Group, Swindon, UK.
Canine acanthomatous ameloblastoma (CAA) is an invasive benign epithelial odontogenic tumour most commonly affecting the mandible of large breed dogs. To the author's knowledge, this report describes the first computer-aided design patient-specific implant (PSI) that has been placed for a critical sized bone defect in mandibular reconstruction of a dog in the UK. The aim was to restore mandibular stability using a regenerative approach combining a titanium locking plate and compression-resistant matrix infused with recombinant human bone morphogenetic protein-2 (rhBMP-2) to bridge the 85 mm mandibular defect created by a segmental mandibulectomy.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Introduction: Bone spinal metastases disrupt the bone homeostasis, inducing a local imbalance in the bone formation and/or resorption, with consequent loss of the structural optimisation of the vertebrae and increase of the risk of fracture. Little is known about the microstructure of the metastatic tissue, the microstructure of the tissue surrounding the lesion, and how it does compare with vertebrae with no lesions observed on the biomedical images. A comprehensive assessment of the microstructural properties of the entire vertebral body can be obtained with micro computed tomography.
View Article and Find Full Text PDFJ Bone Oncol
February 2025
Liaoning Provincial People's Hospital, Shenyang, Liaoning, China.
Osteosarcoma is a common malignant tumor found in adolescents, characterized by a high metastatic potential and poor prognosis, but it is sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of regulated cell death induced by excessive iron accumulation, leading to lipid peroxidation that results in cellular dysfunction and death. Naringenin is a flavonoid known for its anti-cancer properties, yet its role in osteosarcoma has not been thoroughly studied.
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