AI Article Synopsis
- An investigation into the role of the inhibitory receptor Programmed Death-1 (PD-1) in 273 patients with autoimmune myasthenia gravis revealed no significant genetic association with the disease through SNP genotyping.
- Gene expression levels in patients did not differ from those in healthy controls.
- However, there were higher levels of PD-1 on T cells and its ligand PD-L1 on monocytes in patients, indicating a potential natural regulatory role for PD-1 in myasthenia gravis.
Article Abstract
The key role of an inhibitory receptor, Programmed Death-1, has been evaluated in 273 patients with autoimmune myasthenia gravis. At the genetic level, SNP's genotyping showed no significant association to the disease. Gene expressions in patients were not different from that in controls. Interestingly, at the cell-surface protein level, there were significant elevated levels of PD-1 on T cells and its ligand PD-L1 on monocytes in the patients compared to controls. However, we could not demonstrate any secreted soluble forms of PD-1 among the patients and controls. Thus, our study shows PD-1 might have a natural regulatory property behind MG.
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| http://dx.doi.org/10.1016/j.jneuroim.2007.09.019 | DOI Listing |
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