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Identification of novel anti-leishmanials targeting glutathione synthetase of the parasite: a drug repurposing approach.
FEBS Lett
September 2024
School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, India.
Drug repurposing has emerged as an effective strategy against infectious diseases such as visceral leishmaniasis. Here, we evaluated four FDA-approved drugs-valrubicin, ciclesonide, deflazacort, and telithromycin-for their anti-leishmanial activity on Leishmania donovani parasites, especially their ability to target the enzyme glutathione synthetase (LdGS), which enables parasite survival under oxidative stress in host macrophages. Valrubicin and ciclesonide exhibited superior inhibitory effects compared to deflazacort and telithromycin, inhibiting the promastigotes at very low concentrations, with IC values of 1.
View Article and Find Full Text PDFAntimicrobial Resistance and Pathogenicity of Isolated from Poultry Meat.
Antibiotics (Basel)
February 2023
Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, USP, Butantã, São Paulo 05508-270, SP, Brazil.
() is an emergent zoonotic food-related pathogen that can be transmitted through the consumption of poultry meat. Data regarding the pathogenicity and resistance of are still scarce, and the presence of virulent MDR strains of this zoonotic pathogen in poultry meat is an issue of particular concern to public health. This study aimed to characterize the pathogenicity and antimicrobial resistance profiles of strains isolated from poultry meat sold at retail markets in São Paulo, Brazil.
View Article and Find Full Text PDFspp. is a globally emerging zoonotic and foodborne pathogen. However, little is known about its prevalence and antimicrobial resistance in China.
View Article and Find Full Text PDFPrevalence and Characterization of Food-Related Methicillin-Resistant (MRSA) in China.
Front Microbiol
February 2019
State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.
Methicillin-resistant (MRSA) is an emerging pathogen that is difficult to treat due to the multiresistance of the bacteria upon infection. From 2011 to 2016, 1581 strains were isolated from 4300 samples from retail foods covering most provincial capitals in China. To determine the prevalence of food-related MRSA and its genetic background in China, antibiotic resistance, staphylococcal toxin genes, staphylococcal cassette chromosome () typing, -typing and MLST were carried out in this study.
View Article and Find Full Text PDFRibonucleotide reductase as a drug target against drug resistance Mycobacterium leprae: A molecular docking study.
Infect Genet Evol
June 2018
Department of Physics, Deen Dayal Upadhyay Gorakhpur University, Civil Lines, Gorakhpur, India.
Leprosy is a chronic infection of skin and nerve caused by Mycobacterium leprae. The treatment is based on standard multi drug therapy consisting of dapsone, rifampicin and clofazamine. The use of rifampicin alone or with dapsone led to the emergence of rifampicin-resistant Mycobacterium leprae strains.
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