AI Article Synopsis
- Dictyostelium is a key model organism for studying chemotaxis, and recent research has revealed new insights into the underlying mechanisms.
- The previously believed essential role of phosphatidylinositol 3-kinase (PI 3-kinase) in chemotaxis has been challenged, with new pathways, like phospholipase A2 homologues, gaining attention for their importance.
- Current studies are focusing on the diverse methods cells use to form pseudopods and how these structures help regulate movement in response to chemical signals, suggesting a more complex process than previously thought.
Article Abstract
Dictyostelium is one of the most successful and best-studied organisms for research into the mechanisms that drive chemotaxis. In this review, we discuss recent progress in the field. Phosphatidylinositol 3-kinase (PI 3-kinase), previously thought by some to be essential for chemotaxis, has now been proven to be dispensable. However, other pathways are emerging which might connect signalling to migration. In particular, phospholipase A2 homologues appear to play an important role. Other areas of current interest include the fundamental processes by which cells move - pseudopods have been found to be generated in many different ways. Similarly, chemotaxis may be mediated by multiple checks on the number of pseudopods, rather than by simple generation of new pseudopods on demand. Finally, we review several advances in the theory of how cells convert shallow, noisy chemical gradients into overt movement.
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| http://dx.doi.org/10.1016/j.mib.2007.10.004 | DOI Listing |
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