A variety of novel heterocyclic compounds were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574968 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2007.10.020 | DOI Listing |
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