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Resveratrol attenuates cisplatin-induced nephrotoxicity in rats. | LitMetric

Resveratrol attenuates cisplatin-induced nephrotoxicity in rats.

Arch Toxicol

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. Do Café, s/n, 14041-903 Ribeirao Preto, Brazil.

Published: June 2008

AI Article Synopsis

  • Cisplatin, a common cancer treatment, often causes nephrotoxicity, or kidney damage, which limits its use in patients.
  • Resveratrol, a natural compound, showed protective effects against kidney damage in rats treated with cisplatin.
  • The study found that resveratrol reduced indicators of renal injury and inflammation, suggesting it could help mitigate the adverse effects of cisplatin on the kidneys.

Article Abstract

Cisplatin is an antitumor drug widely used in the treatment of many malignant tumors. However, the most common adverse effect, nephrotoxicity, limits the use of this drug in many cancer patients. Resveratrol is a phytoalexin that presents highly efficient protection in experimental nephrotoxicity models. This study evaluated the effect of resveratrol on cisplatin-induced kidney damage. Male Wistar rats were treated with resveratrol (25 mg/kg b.w., i.p.) before the administration of cisplatin (5 mg/kg b.w., i.p.) and killed 2 or 5 days later. Blood and urine samples were collected and the kidneys were removed. Rats from the cisplatin group showed acute tubular cell necrosis and increased immunostaining for ED1 (macrophages/monocytes) and T-lymphocytes in the renal cortex and outer medulla when compared with the control group. These alterations were less intense in animals pre-treated with resveratrol. Moreover, indicators of renal injury such as increased serum creatinine levels, urinary volume and urinary protein caused by the administration of cisplatin, were also significantly reduced with resveratrol. Increased lipid peroxidation and glutathione depletion in tissue were attenuated by resveratrol. In conclusion, resveratrol attenuated the cisplatin-induced structural and functional renal changes by reducing free radicals and inhibiting inflammatory cell infiltrates.

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Source
http://dx.doi.org/10.1007/s00204-007-0262-xDOI Listing

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