Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nsmb1340 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Differences in Rejuvenation Mechanisms and Physical Properties of Aged Styrene-Butadiene-Styrene (SBS)-Modified Bitumen by Mono-Epoxy and Di-Epoxy Compounds.
Polymers (Basel)
December 2024
Key Laboratory for Special Area Highway Engineering of Ministry of Education, Chang'an University, South 2nd Ring Road Middle Section, Xi'an 710064, China.
Studying the mechanisms and effects of rejuvenators on SBS-modified bitumen is crucial for repairing degraded SBS and recycling aged SBS-modified bitumen (ASMB), thereby contributing to the sustainable development of bitumen pavements. This research examines the roles of mono-epoxy Alkyl (C12-C14) glycidyl ether (AGE) and di-epoxy 1,6-Hexanediol diglycidyl ether (HDE) under the catalysis of N,N-dimethyl benzyl amine (BDMA) in repairing degraded SBS chains. Aromatic oil (ORSMB)-, AGE-aromatic oil (ARSMB)-, and HDE-aromatic oil (HRSMB)-rejuvenated bitumen are analyzed for their chemical structures, physical properties, and rheological properties.
View Article and Find Full Text PDFStudy of supported heteropolyacid catalysts for one-step DME synthesis from CO and H.
RSC Adv
January 2025
Institute of Technical and Macromolecular Chemistry, University of Hamburg Bundesstraße 45 Hamburg 20146 Germany +49 40 42838 3172.
Dimethyl ether (DME) is a versatile molecule, gaining increasing interest as a viable hydrogen and energy storage solution, pivotal for the transitioning from fossil fuels to environmentally friendly and sustainable energy supply. This research explores a novel approach for the direct conversion of CO to DME in a fixed-bed reactor, combining the Cu/ZnO/AlO methanol synthesis catalyst with supported heteropolyacids (HPAs). First, various HPAs, both commercially available and custom-synthesized, were immobilized on Montmorillonite K10.
View Article and Find Full Text PDFLysine specific demethylase 1 conditional myeloid cell knockout mice have decreased osteoclast differentiation due to increased IFN- gene expression.
JBMR Plus
January 2025
Division of Orthodontics, Department of Developmental and Surgical Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
Article Synopsis
- * The study found that removing the gene LSD1 in myeloid cells (which develop into osteoclasts) leads to increased bone mass and smaller osteoclasts in mice, indicating its role in bone health.
- * The research suggests that LSD1 influences osteoclast differentiation by affecting gene expression, specifically by interacting with other proteins that modify histones, ultimately impacting how osteoclasts function.
Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells.
Sci Rep
November 2024
Department of Molecular Biology, Umeå University, 901 85, Umeå, Sweden.
Lysine-specific histone demethylase 1 (LSD1) is a histone demethylase that plays a critical role in epigenetic regulation by removing the methyl group from mono- and di-methylated lysine 4 on histone H3 (H3K4me1/2), acting as a repressor of gene expression. Recently, catalytically independent functions of LSD1, serving as a scaffold for assembling chromatin-regulator and transcription factor complexes, have been identified. Herein, we show for the first time that LSD1 interacts with chromodomain-helicase-DNA-binding protein 7 (CHD7) in mouse embryonic stem cells (ESCs).
View Article and Find Full Text PDFOutside-in hair contamination by blood containing opiates and opioids.
Forensic Sci Int
December 2024
CHRU-Nancy, Service de Pharmacologie Clinique et Toxicologie, Nancy F-54000, France; Université de Lorraine, CNRS, IMoPA, Nancy F-54000, France. Electronic address:
Hair analysis for drugs has become extensively used for forensic investigation in recent years. To best interpret hair drug content in post-mortem conditions, the extent of external contamination by biological fluids, such as blood, must be taken into account to avoid false positive results. The present study evaluated opiates and opioids incorporation into hair from blood containing different concentrations of morphine (MOR), 6-mono-acetyl morphine (6-AM), codeine (COD), dihydrocodeine (DHC), tramadol (TRA), oxycodone (OXY), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3- diphenyl pyrrolidine (EDDP), buprenorphine (BUP) and norbuprenorphine (NBUP).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!