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| http://dx.doi.org/10.1136/sti.2007.027870 | DOI Listing |
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Vaccine hesitancy and other challenges to sexually transmitted infection vaccine acceptance.
Curr Opin Infect Dis
February 2025
School of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Purpose Of Review: Development of vaccines that protect against sexually transmitted infections (STIs), including for chlamydia, gonorrhea, and syphilis, has progressed greatly over the past decade. However, little research has been conducted to examine STI vaccine acceptance and hesitancy and how these factors may impact future uptake. This review examines literature that could provide additional insights into factors that would impact STI vaccine acceptance and hesitancy.
View Article and Find Full Text PDFDifferential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae.
PLoS Pathog
December 2024
Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Neisseria gonorrhoeae exhibits alarming antibiotic resistance trends and poses a significant challenge in therapeutic management. This study aimed to explore the association of penA alleles with penicillin-binding protein (PBP) occupancy patterns and reduced outer membrane permeability, impacting susceptibility to last-line cephalosporins and potential β-lactam candidates. The whole genome sequence, the MICs and PBP IC50s were determined for 12 β-lactams and β-lactamase inhibitors in 8 clinical isolates with varying β-lactam sensitivity, 2 ATCC, and 3 WHO cephalosporin-resistant reference strains.
View Article and Find Full Text PDFThe Impacts and Consequences of Sexually Transmitted Infections in the United States.
Sex Transm Dis
December 2024
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Article Synopsis
- Millions of people in the U.S. are impacted by STIs each year, leading to serious health consequences like infertility and premature births.
- The review focuses on the epidemiology of four key STIs: C. trachomatis, N. gonorrhoeae, T. pallidum, and HSV, illustrating their effects on individuals and the healthcare system.
- The financial burden of these infections is significant, with C. trachomatis alone causing $824 million in medical costs and substantial loss in quality-adjusted life years (QALYs) for both men and women.
East London Project: a participatory mixed-method evaluation on how removing enforcement could affect sex workers' safety, health and access to services in East London.
Public Health Res (Southampt)
September 2024
Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK.
Background: Sex workers' risk of violence and ill-health is shaped by their work environments, community and structural factors, including criminalisation.
Aim: We evaluated the impact of removing police enforcement on sex workers' safety, health and access to services.
Design: Mixed-methods participatory study comprising qualitative research, a prospective cohort study, mathematical modelling and routine data collation.
Prevalence of HPV infection and anal and cervical cytological abnormalities in transgender people at a referral service in Vitória, Espírito Santo state, Brazil, between 2018 and 2021.
Epidemiol Serv Saude
December 2024
Universidade Federal do Espírito Santo, Programa de Pós-Graduação em Doenças Infecciosas, Vitória, ES, Brazil.
Objectives: The aim of this study was to determine the prevalence of HPV and cytological alterations in the transgender population and contribute to the development of public policies.
Methods: A descriptive study was conducted in a transgender outpatient clinic in Vitória, Espírito Santo state, between 2018 and 2021. Data were collected through interviews and information from medical records.
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