Objective: To investigate the effect of 5F from Pteris semipinnate L on the growth of human pathological scar in nude mice.
Methods: 5F from Pteris semipinnate L was administered at different doses in nude mouse models bearing human pathological scars. The morphology, histology, tumor growth factor-beta1 and type I collagen content of the scar tissues were examined after the administration.
Results: Administration of 5F significantly reduced the volume of the implanted pathological scars in the nude mouse models, and histologically, the scar tissue exhibited a transition to the normal scar architecture with decreased TGF-beta1 and type I collagen content.
Conclusion: 5F could effectively inhibit the growth of pathological scars in nude mice.
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