The synthesis and gamma-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11-47) are described. Inhibition of brain Abeta in transgenic mice was demonstrated by two of these compounds (23 and 44).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2007.10.105 | DOI Listing |
Publication Analysis
Top Keywords
nitrogen-appended n-alkylsulfonamides
8
n-alkylsulfonamides inhibitors
4
inhibitors gamma-secretase
4
gamma-secretase synthesis
4
synthesis gamma-secretase
4
gamma-secretase inhibition
4
inhibition data
4
data series
4
series nitrogen-appended
4
n-alkylsulfonamides 11-47
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!