Background And Purpose: Photon beams used in IMRT treatments with high energies (>10 MV) are contaminated with neutrons. Measurement of this neutron dose is of significance to the overall risk estimate of high energy radiotherapy.
Materials And Methods: For measuring neutron doses a paired magnesium and boron coated magnesium chamber system was used. All measurements were performed inside the solid water phantom EasyCube using abdominal extensions. 4 different clinical treatment plans were studied.
Results: The measured neutron dose showed to be homogeneous inside the phantom and increased with increased number of applied monitor units. The sum over all fractions showed neutron doses of 1-2 mGy, depending on the kind of treatment.
Conclusions: Using large conversion factors of 25 Sv/Gy, none of the studied treatment plans exceeded dose equivalents of 50 mSv for the whole treatment. This dose equivalent has to be considered whole body dose due to the homogeneous distribution of neutrons.
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http://dx.doi.org/10.1016/j.radonc.2007.10.033 | DOI Listing |
Drug Deliv Transl Res
December 2024
Thiomatrix Forschungs- Und Beratungs GmbH, Trientlgasse 65, 6020, Innsbruck, Austria.
The aim of this study was to develop an alternative strategy to sufficiently increase the lipophilicity of anionic model macromolecules (MM) without the use of cationic counterions. Enoxaparin (ENO), insulin (INS) and poly-L-glutamic acid (PLG) were ion paired with anionic surfactants (sodium decanoate (DEC), sodium dodecyl sulfate (SDS), sodium stearate (SS) and sodium octadecyl sulfate (SOS)), mediated by divalent cations such as magnesium, calcium and zinc. Complexes were evaluated regarding their precipitation efficiency and logD.
View Article and Find Full Text PDFDalton Trans
December 2024
Univ Rennes, CNRS, ISCR (Institut des Sciences Chimiques de Rennes) - UMR 6226, F-35000 Rennes, France.
The pentafluorophenyl moiety CF was succesfully employed for the first time in lead(II) chemistry. We are reporting on the stable and soluble organolead(II) polymer [Pb(CF)(dx)] (dx = dioxane). An example of a Pb(II) "ate" complex paired with a trimetallic magnesium cation is also presented.
View Article and Find Full Text PDFAdv Nutr
December 2024
Texas A&M Agriculture, Food and Nutrition Evidence Center, Fort Worth, Texas, United States; Department of Nutrition, Texas A&M University, College Station, Texas, United States.
Background: Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes.
Objectives: To describe the scope of the evidence associated with seafood-related toxicant exposure and child outcomes and to identify toxicant-outcome pairs that may have sufficient evidence to conduct a systematic review.
Methods: We included studies examining seafood toxicant exposure during pregnancy, lactation, and childhood, and child outcomes.
Toxicol Appl Pharmacol
December 2024
Department of Fishery Sciences, Vidyasagar University, Midnapore 721102, West Bengal, India. Electronic address:
A frequently utilized plasticizer is di-(2-ethylhexyl) phthalate (DEHP), considered a ubiquitous contaminant in the environment and reported to have severe impacts on animals. Although it disrupts the female reproductive system in mammals, little is known about how it effects on fish reproduction. The reproductive parameters of female adult koi carp (Cyprinus carpio) were investigated in this study subjected to environmentally relevant exposure of DEHP (1, 10 and 100 μg/L).
View Article and Find Full Text PDFNat Struct Mol Biol
November 2024
Department of Experimental Medical Science, Lund University, Lund, Sweden.
The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, particularly for the eukaryotic Mrs2 members. Here, we report closed and open Mrs2 cryo-electron microscopy structures, accompanied by functional characterization.
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