The Experimental Therapeutics Center (ETC) has been established at Biopolis to advance translational research by bridging the gap between discovery science and commercialization. We describe the Electronic Research Habitat at ETC, a comprehensive hardware and software infrastructure designed to effectively manage terabyte data flows and storage, increase back office efficiency, enhance the scientific work experience, and satisfy rigorous regulatory and legal requirements. Our habitat design is secure, scalable and robust, and it strives to embody the core values of the knowledge-based workplace, thus contributing to the strategic goal of building a "knowledge economy" in the context of Singapore's on-going biotechnology initiative.
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http://dx.doi.org/10.1002/biot.200700190 | DOI Listing |
STAR Protoc
January 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China. Electronic address:
Human pluripotent stem cells (hPSCs) provide a powerful platform for generating hematopoietic progenitor cells (HPCs) and investigating hematopoietic development. Here, we present a protocol for maintaining hPSCs and inducing their differentiation into HPCs through the endothelial-to-hematopoietic transition (EHT) on vitronectin-coated plates. We outline steps for evaluating the efficiency of HPC generation and assessing their potential to differentiate into various hematopoietic lineages.
View Article and Find Full Text PDFEnviron Pollut
January 2025
Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, 361005, China.
Noctiluca scintillans is one of the most common harmful algal species worldwide. In this study, a MaxEnt model was constructed to calculate the present and future habitat suitability of N. scintillans in the China Sea.
View Article and Find Full Text PDFChemosphere
January 2025
Center for the Development of Functional Materials (CDMF), Federal University of São Carlos (UFSCar), Washington Luís Road, Km 235, 13565-905, São Carlos, SP, Brazil.
Innovative applications of cobalt tungstate nanoparticles (CoWO NPs) are directly linked to their increased production and consumption, which can consequently increase their release into aquatic ecosystems and the exposure of organisms. Microalgae are autotrophic organisms that contribute directly to global primary productivity and provide oxygen for maintaining many organisms on Earth. In this paper, we assessed the toxicity of CoWO NPs when in contact with the freshwater microalga Raphidocelis subcapitata (Chlorophyceae).
View Article and Find Full Text PDFEnviron Res
January 2025
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources of China, State Key Laboratory Breeding Base of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Xiamen 361005, China; Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519000, China. Electronic address:
Plastic waste that ends up in the deep sea is becoming an increasing concern. However, it remains unclear whether there is any microflora capable of degrading plastic within this vast ecosystem. In this study, we investigated the bacterial communities associated with different types of plastic-polyamide-nylon 4, 6 (PA), polyethylene (PE), polyethylene terephthalate (PET), and polystyrene (PS)-after one year of in situ incubation in the pelagic deep sea of the Western Pacific.
View Article and Find Full Text PDFEnviron Res
January 2025
State Environmental Protection Key Laboratory of Marine Ecosystem Restoration, National Marine Environmental Monitoring Center, Dalian 116023, China; College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China. Electronic address:
Shipboard domestic sewage, encompassing both black water and gray water, has the potential to transport significant quantities of environmentally harmful microplastics, a concern that has garnered increasing global attention. In this study, Fourier infrared (FTIR) detection was used to detect microplastics in marine domestic wastewater. The primary objective was to evaluate the abundance and characteristics of microplastics present in ship domestic sewage, investigate potential sources and influencing factors, and assess the ecological risks associated with ship sewage through analyses of microplastic abundance and hazard indices.
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