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Environmental thresholds of semiaquatic bugs (Heteroptera, Gerromorpha) as an indicator of environmental change in Amazon streams.
Environ Monit Assess
January 2025
Programa de Pós-Graduação em Ecologia (PPGECO), Universidade Federal do Pará (UFPA), Instituto de Ciências Biológicas (UFPA), Belém, Pará, Brazil.
Freshwater ecosystems under the influence of human activities are subject to multiple environmental stressors that lead to biodiversity loss and habitat modification. In recent years, various organisms have been used as bioindicators to detect environmental changes by their ability to perceive changes in community attributes. A good example is the semiaquatic bugs (Hemiptera, infra order Gerromorpha) that act as predators and are sensitive to subtle changes in environmental conditions.
View Article and Find Full Text PDFEndothelial FOXM1 and Dab2 promote diabetic wound healing.
JCI Insight
January 2025
Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
Diabetes mellitus can cause impaired and delayed wound healing, leading to lower extremity amputations; however, the mechanisms underlying the regulation of vascular endothelial growth factor-dependent (VEGF-dependent) angiogenesis remain unclear. In our study, the molecular underpinnings of endothelial dysfunction in diabetes are investigated, focusing on the roles of disabled-2 (Dab2) and Forkhead box M1 (FOXM1) in VEGF receptor 2 (VEGFR2) signaling and endothelial cell function. Bulk RNA-sequencing analysis identified significant downregulation of Dab2 in high-glucose-treated primary mouse skin endothelial cells.
View Article and Find Full Text PDFApplication of Self-Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration.
J Biomed Mater Res B Appl Biomater
February 2025
Tianjin Hospital, Tianjin, China.
Intervertebral disc degeneration (IDD) is one of the leading causes of chronic pain and disability, and traditional treatment methods often struggle to restore its complex biomechanical properties. This article explores the innovative application of self-healing hydrogels in the treatment of IDD, offering new hope for disc repair due to their exceptional self-repair capabilities and adaptability. As a key support structure in the human body, intervertebral discs are often damaged by trauma or degenerative changes.
View Article and Find Full Text PDFVascularized composite allograft deceased donation in the United States.
Front Transplant
January 2025
Organ Donation Services, New England Donor Services, Waltham, MA, United States.
Vascularized composite allograft (VCA) transplantation represents a significant advancement in reconstructive surgery and offers hope to individuals who experienced congenital disorders or severe tissue injuries to restore physical appearance, function, and enhance quality of life. VCA recovery introduces complexities to conventional solid organ recovery, and there remain concerns regarding the potential impact of VCA recovery on non-VCA organs for transplant. The current retrospective study examines deceased donor characteristics and observed-to-expected (O/E) organ yield ratios for 51 VCA donors recovered in the US between July 4, 2014 and March 31, 2024, compared with a contemporary cohort of non-VCA donors recovered in 2023.
View Article and Find Full Text PDFInternational Expert-Based Consensus Definition, Classification Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
Purpose: Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 classification systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ.
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