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A Scientific Program in Regenerative Engineering (ASPIRE): A Prospective Program Aimed at Tackling Health Disparities in the USA.
J Racial Ethn Health Disparities
December 2024
The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Storrs, CT, 06268, USA.
The continued low numbers of Blacks in STEMM (Science, Technology, Engineering, Mathematics, and Medicine) represent an American crisis that threatens growing awareness and efforts to effectively address health disparities that affect the Black population. Regenerative engineering is an emerging STEMM field that seeks to combine principles from engineering, life sciences, physics, and medicine to develop new technologies for repairing and regenerating damaged tissues and organs. We believe that regenerative engineering has the potential to address some of the root causes of health disparities by developing new approaches that are more accessible and affordable, particularly for low-income communities and people living in rural areas.
View Article and Find Full Text PDFClasses of Stem Cells: From Biology to Engineering.
Regen Eng Transl Med
September 2024
The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, 263 Farmington Avenue, Farmington, CT 06030-3711, USA.
Purpose: The majority of adult tissues are limited in self-repair and regeneration due to their poor intrinsic regenerative capacity. It is widely recognized that stem cells are present in almost all adult tissues, but the natural regeneration in adult mammals is not sufficient to recover function after injury or disease. Historically, 3 classes of stem cells have been defined: embryonic stem cells (ESCs), adult mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs).
View Article and Find Full Text PDFFunctions and Effectiveness of Unloader, Patellofemoral, and Knee Sleeve Orthoses: A Review.
Regen Eng Transl Med
June 2024
The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, USA.
Article Synopsis
- Knee orthoses are commonly used to help manage knee deficiencies, particularly in patients with osteoarthritis, which is a leading cause of disability.
- This literature review aims to inform clinicians, patients, and researchers about the main types of knee braces—unloader, patellofemoral, and knee sleeves—by discussing their design, function, and effectiveness.
- While many patients feel they benefit from wearing these braces, the scientific evidence supporting their effectiveness remains inconclusive.
Animal Models of Osteoarthritis: Updated Models and Outcome Measures 2016-2023.
Regen Eng Transl Med
June 2024
The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, 263 Farmington Avenue, Farmington, CT 06030-3711, USA.
Purpose: Osteoarthritis (OA) is a global musculoskeletal disorder that affects primarily the knee and hip joints without any FDA-approved disease-modifying therapies. Animal models are essential research tools in developing therapies for OA; many animal studies have provided data for the initiation of human clinical trials. Despite this, there is still a need for strategies to recapitulate the human experience using animal models to better develop treatments and understand pathogenesis.
View Article and Find Full Text PDFDevelopment of porcine skeletal muscle extracellular matrix-derived hydrogels with improved properties and low immunogenicity.
Proc Natl Acad Sci U S A
May 2024
The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Farmington, CT 06030.
Hydrogels derived from decellularized extracellular matrices (ECM) of animal origin show immense potential for regenerative applications due to their excellent cytocompatibility and biomimetic properties. Despite these benefits, the impact of decellularization protocols on the properties and immunogenicity of these hydrogels remains relatively unexplored. In this study, porcine skeletal muscle ECM (smECM) underwent decellularization using mechanical disruption (MD) and two commonly employed decellularization detergents, sodium deoxycholate (SDC) or Triton X-100.
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