AI Article Synopsis
- The development of cholera vaccines can serve as a platform for delivering other foreign antigens to the immune system.
- Researchers can use different methods, such as genetic modifications or combining proteins, to incorporate these foreign antigens into cholera vaccine components.
- Advances in understanding the genes of Vibrio cholerae during infection offer new ways to create enhanced vaccine vectors that provide immunity against various pathogens.
Article Abstract
The development of safe, immunogenic and protective cholera vaccine candidates makes possible their use as a versatile antigen delivery platform. Foreign antigens can be delivered to the immune system with cholera vaccines by expressing heterologous antigens in live attenuated vectors, as fusion proteins with cholera toxin subunits combined with inactivated Vibrio cholerae whole cells or by exposing them on the surface of V. cholerae ghosts. Progress in our understanding of the genes expressed by V. cholerae during infection creates unprecedented opportunities to develop an improved generation of vaccine vectors to induce immune protection against a broad range of pathogenic organisms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753531 | PMC |
| http://dx.doi.org/10.1007/s10529-007-9594-0 | DOI Listing |
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