Mammary glands become functional only in adult life but their development starts in the embryo. Initiation of the epithelial bud and ductal outgrowth are coordinated through short-range signals between epithelium and mesenchyme. Studies of natural and induced mouse mutants in which early mammary development is perturbed have identified genetic networks that regulate specific steps in these processes. Some of these signals contribute to aberrant mammary development in humans and are deregulated in cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nrg2227 | DOI Listing |
Publication Analysis
Top Keywords
mammary development
8
cooperation signalling
4
signalling pathways
4
pathways embryonic
4
mammary
4
embryonic mammary
4
mammary gland
4
development
4
gland development
4
development mammary
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!