The Pechmann reaction of substituted phenols 1a-e with methyl acetoacetate (2) can be activated by boron trifluoride dihydrate (3) to give the corresponding 4-methyl- coumarin derivatives 4a-e in excellent yield (98-99 %).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147532 | PMC |
| http://dx.doi.org/10.3390/10070762 | DOI Listing |
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